Grace is a new language whose types are structural, gradual, and optional. Minigrace is a compiler for the Grace language. Minigrace itself was written with gradual types. We describe the implementation of the compiler and future challenges for it.

Introduction . The low solubility of active pharmaceutical ingredients (APIs) in the physiological pH range intestinal tract can adversely affect their absorption and bioavailability. Various methods increasing APIs have been proposed recent decades. Among them there are preparation solid dispersions, micronization, solubilization other methods, including ones based on amorphization crystalline...

BACKGROUND The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts outcome in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). Whether NT-proBNP has incremental prognostic value beyond established risk strategies is still questionable. PURPOSE To evaluate the predictive value of NT-proBNP for 30-day mortality over and beyond the Global Registry of Acute ...

Global Registry of Acute Coronary Events (GRACE) risk score and red blood cell distribution width (RDW) content can both independently predict major adverse cardiac events (MACEs) in patients with acute coronary syndrome (ACS). We investigated the combined predictive value of RDW and GRACE risk score for cardiovascular events in patients with ACS undergoing percutaneous coronary intervention (P...

[1] The satellite Gravity Recovery and Climate Experiment (GRACE) provides data describing monthly changes in the geoid, which are closely related to changes in vertically integrated terrestrial water storage. Unlike conventional point or gridded hydrologic measurements, such as those from rain gauges, stream gauges, rain radars, and radiometric satellite images, GRACE data are sets of Stokes c...

When a domain name is registered, the registrant is given five days to cancel for a full refund. While the purpose of this grace period is to protect those who innocently err in the registration process, speculators have taken advantage of the grace period through a process called “domain tasting.” These “domain tasters” register hundreds of thousands of domain names and cancel the vast majorit...

[1] In this study, we estimate a time series of geocenter anomalies from a combination of data from the Gravity Recovery and Climate Experiment (GRACE) satellite mission and the output from oceanmodels. Amatrix equation is derived relating total geocenter variations to the GRACE coefficients of degrees two and higher and to the oceanic component of the degree one coefficients. We estimate the o...

BACKGROUND Innovative technologies that enable the collection of family history information and the assessment of breast cancer risk have a potential to enhance the quality of preventive care. We developed a computerized tool that supports stratification of breast cancer risk, genetic risk assessment in the clinical environment (GRACE). METHODS In a preliminary evaluation of the tool's impact...

[1] Satellite gravity measurements from the Gravity Recovery and Climate Experiment (GRACE) provide new quantitative measures of the 2005 extreme drought event in the Amazon river basin, regarded as the worst in over a century. GRACE measures a significant decrease in terrestrial water storage (TWS) in the central Amazon basin in the summer of 2005, relative to the average of the 5 other summer...