I this issue, Arbyn et al (see p. 167) update the evidence about the accuracy of liquid-based cytology compared with conventional cytology, and the results are not encouraging.1 In summary, best evidence suggests that liquid-based cytology does not lead to more disease detection and appears to increase false-positive testing, sobering news given that over 80% of U.S. obstetrician–gynecologists ...

The atypical squamous cell/squamous intraepithelial lesion (ASC/SIL) ratio has been used as a surrogate quality control tool for specificity and uncertainty for cytopathologists. Whether this ratio is useful for cytotechnologists is not known. During an 8-month period, the sensitivity of screening for 11 cytotechnologists was determined using rapid prescreening. The ASC/SIL ratio for each cytot...

PURPOSE To study the prevalence of CIN2+ diagnosis in women with atypical Papaniculoau (Pap) smears to suggest appropriate management option for Thai health care. MATERIALS AND METHODS Data from all patients with liquid based cytology with human papillomavirus (HPV) testing between May 2013 - May 2016 were collected from medical records. Women with atypical cervical Pap smears were recruited....

CONTEXT Anal cytology is being used more frequently for anal cancer screening, yet many cytologists are unfamiliar with it. OBJECTIVE To describe the performance of anal cytology in the College of American Pathologists' Interlaboratory Comparison Program in Non-Gynecologic Cytology (CAP NGC) educational slide program during a 6-year time span, from 2006 to 2011, using participant responses (p...

Results HPV-HR (high-risk) was positive in 377 cases, HPV-LR (low-risk) was positive in 165 cases and in 35 cases no HPV typing was performed. The herpes virus type 2 infection was present in 2 cases. Cytology showed LSIL (low grade squamous intraepithelial lesion) in 329 cases and HSIL (high grade squamous intraepithelial lesion) in 189 cases. Histological examination revealed cervical intraep...

OBJECTIVE To determine the prevalence of cervical intraepithelial neoplasia (CIN) 2-3 (high-grade CIN) among women with Atypical Squamous Cells of Undetermined Significance (ASC-US) Pap smear. MATERIAL AND METHOD A retrospective medical record review of220 women with ASC-US cervical Pap smear, including age, menstruation status, parity, placed of residence, occupation, main complaint, and def...

I this issue, Arbyn et al (see p. 167) update the evidence about the accuracy of liquid-based cytology compared with conventional cytology, and the results are not encouraging.1 In summary, best evidence suggests that liquid-based cytology does not lead to more disease detection and appears to increase false-positive testing, sobering news given that over 80% of U.S. obstetrician–gynecologists ...

OBJECTIVE We sought to test the diagnostic efficacy of a low-cost, liquid-based cervical cytology that could be implemented in low-resource settings. MATERIALS AND METHODS A prospective, split-sample Pap study was performed in 595 women attending a cervical cancer screening clinic in rural El Salvador. Collected cervical samples were used to make a conventional Pap (cell sample directly to gl...

In this issue of the Journal, Lee and colleagues 1 from Hong Kong describe their assessment of the impact of the 2001 Bethesda System (TBS) revisions on their cytology practice. The primary focus of the study was to assess the impact of the conversion from TBS 1991 to the 2001 version on the frequency of atypical squamous cells (ASC) diagnoses. As noted in prior commentaries, ASC is not a diagn...

The prevalence of cervical human papillomavirus (HPV) in South African women (n = 1,073) increased from 20.4% (173/848) in women with normal cytology to 41.7% (48/115) in women with atypical squamous cells of undetermined significance, 70.2% (40/57) in women with low-grade squamous intraepithelial lesions, and 83% (44/53) in women with high-grade squamous intraepithelial lesions (HSILs). HPV ty...