Mass transport within native human tissue enables delivery of nutrients to and removal of waste from cells embedded in a dense 3D matrix material. Blood flow through cardiovascular networks (e.g., veins and arteries) provides nutrients that can diffuse into the tissue. The ability to deliver nutrients deeper into the tissues is a critical issue in the development of large-scale multicellular or...

In drug development, specificity and the avoidance of off-target effects are the initial holy grails, with the ultimate goal of obtaining maximal in vivo efficacy coupled with minimal toxicity. Tumors, however, can be very efficient at nullifying the benefits of what could otherwise be good drugs. Tumors achieve these effects through a variety of mechanisms, one of which is drug resistance. Acq...

abstract         sasanian dynasty, who governed as the last and the most glorious dynasty before islam in iran, has had an important role in enrichment of sasanian silver works and we owe the majority of silver works to this era. metalwork is one of the oldest arts iniranian civilization. the prominent metalwork crafts‚ left from different ages‚ acknowledge this fact. the art of this era has di...

Three publications were selected based on the strength of the research questions, but also because they represent different research designs that are used with varying degrees of frequency in the paediatric literature. The first, a prospective, longitudinal cohort observation study from 7 to 16 years with girls and boys reports an intrinsic reduction in absolute resting energy expenditure after...

Speaker: Adam Barett (Department of Informatics, University Sussex, UK) Synergistic and redundant information sharing in Gaussian systems To fully characterize the information that two `source' variables carry about a third `target' variable, one must decompose the total information into redundant, unique and synergistic components. However Shannon's theory of information does not provide formu...