The skins and seeds of grapes are known to be rich sources of phenolic compounds, both flavonoids and non-flavonoids. The aim of the present study is to determine polyphenolic composition, antioxidant potential along with free radical scavenging activity and antimicrobial properties of ethanol extract of Grape skin and seed. Grape seed showed high antioxidant and antimicrobial activity compared...

OBJECTIVE Mucositis is a serious disorder of the gastrointestinal tract that results from cancer chemotherapy. We investigated the effects of increasing grape seed extract doses on the severity of chemotherapy in a rat model and its coincident impact on chemotherapeutic effectiveness in colon cancer cells. DESIGN Female Dark Agouti rats were gavaged with grape seed extract (400-1000 mg/kg) or...

objective(s):diabetes plays an important role in the induction of the liver injury. grape seed proanthocyanidin (gsp) have a wide range of medicinal properties against oxidative stress. in this study we evaluated antioxidant effects of gsp on liver in streptozotocin-induced diabetic rats. materials and methods: thirty male sprague–dawley rats were divided into three groups: control, untreated d...

Polyphenol-rich grape seeds have a beneficial effect on human health. The present study was performed to investigate the effects of grape seeds on antioxidant activities in rats. Male Sprague-Dawley rats were randomly divided into a control diet group (C), a high-fat diet group (HF), a 5% grape seed-supplemented control diet group (G), and a 5% grape seed-supplemented high-fat diet group (HG). ...

Seven treatments (activated charcoal, bentonite, PVPP, yeast cell walls, potassium caseinate, zeolite and grape seed oil) were evaluated for their efficacy in decreasing the concentration of geosmin, responsible for earthy off-flavour in wine. In the red wine the potassium caseinate and grape seed oil treatments decreased the concentration of geosmin by 14% and 83%, respectively, while in the w...

Purpose. This study investigated the long-term resin-dentin bond strength of dentin biomodified by proanthocyanidin-rich (PA) agents. Materials and Methods. Forty molars had their coronal dentin exposed, etched, and treated for 10 minutes with 6.5% grape seed extract (GSE), 6.5% cocoa seed extract ethanol-water (CSE-ET), 6.5% cocoa seed extract acetone-water (CSE-AC), and distilled water (CO). ...

INTRODUCTION Streptococcus mutans has been implicated as primary microorganisms which cause dental caries in humans. There has been an increased interest in the therapeutic properties of some medicinal plants and natural compounds which have demonstrated antibacterial activities. Grape is one of the plants of this group which contains tannin and polyphenolic compound. AIM To evaluate and comp...

UNLABELLED Grape juice processing by-products, grape seed and pomace are a rich source of procyanidins, compounds that may afford protection against chronic disease. This study was undertaken to identify optimal extrusion conditions to enhance the contents of monomers and dimers at the expense of large molecular weight procyanidin oligomers and polymers in grape seed and pomace. Extrusion varia...