vascular endothelial growth factor (vegf) is a multifunctional cytokine with distinct functions in angiogenesis, lymphangiogenesis, vascular permeability, and hematopoiesis. vegf is a highly conserved, disulfide-bonded dimeric glycoprotein of 34 to 45 kda produced by several cell types including fibroblasts, neutrophils, endothelial cells, and peripheral blood mononuclear cells, particularly t ...

Phospholipase Cγ1 (PLCγl) and p21 guanosine triphosphatase (GTPase) activating protein (GAP) bind to and are phosphorylated by activated growth factor receptors. Both PLCγl and GAP contain two adjacent copies of the noncatalytic Src homology 2 (SH2) domain. The SH2 domains of PLCγl synthesized individually in bacteria formed high affinity complexes with the epidermal growth factor (EGF)or plate...

conclusions p. aeruginosa and s. marcescens can be good candidates for the detoxification of cr (vi) in soltan abad river. results the results indicated that pseudomonas aeruginosa and serratia marcescens were the most resistant bacteria with mics of 200 and 150 mg/l, respectively. both bacteria completely reduced 25 and 50 mg/l of cr (vi) in 36 hours and 48 hours, respectively. the growth rate...

background: basic fibroblast growth factor (bfgf) is a glycoprotein with stimulating ability of angiogenesis. in addition, bfgf plays an important role in wound healing process in some tissues for example gastrointestinal tract, but its ability for discrimination of various stages of wound severity in these diseases was not reported. therefore, we aimed to determine the bfgf levels in gastric u...

conclusions based on our study, in vivo prepared e/sa may be considered as a good candidate for animal immunization. results our results showed that the serum levels of anti-e/sa immunoglobulins significantly increased in all of the immunized groups. the differences of the serum levels of tgf-β between the groups were statistically significant at days 28 and 56 after immunization with e/sa. bac...

background: the present study investigated the functional maturity of oligodendrocyte derived from rat bone marrow stromal cells (bmsc). methods: the bmsc were isolated from female sprague-dawley rats and evaluated for different markers, such as fibronectin, cd106, cd90, oct-4 and cd45. transdifferentiation of olc from bmsc was obtained by exposing the bmsc to dmso and 1 µm all-trans-retinoic a...

background: new blood vessels formation is a critical step in tumor progression. vascular density affects the clinical outcome and prognosis of malignant tumors. the aim of this study was to investigate the relation between the vascular endothelial growth factor (vegf) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (oscc).   method...

uncontrolled hypertension is well- known to give rise to systemic complications involving multiple central organs. artherosclerosis leads to damage of the retinal vessels wall, contributing to venous stasis, thrombosis and finally, occlusion. retinal vein occlusions compromise vision through development of ischaemic maculopathy, macular oedema, and rubeotic glaucoma. laser photocoagulation rema...