MOTIVATION Group-wise pattern analysis of genes, known as gene-set analysis (GSA), addresses the differential expression pattern of biologically pre-defined gene sets. GSA exhibits high statistical power and has revealed many novel biological processes associated with specific phenotypes. In most cases, however, GSA relies on the invalid assumption that the members of each gene set are sampled ...

Background & Aims: Considering the important role of stress in intensifying gastroesophageal reflux disease (GERD) symptoms, the aim of the present study was to determine the effectiveness of stress management training in reducing symptoms in patients with GERD. Methods: In the present semi-experimental study, a pre-test post-test design with control group was used. From among the patients who ...

In this paper I evaluate the contribution of R&D investments to productivity growth. The basis for the analysis are the free entry condition and the fact that most R&D innovations are embodied. Free entry yields a relationship between the resources devoted to R&D and the growth rate of technology. Since innovators are small, this relationship is not directly affected by the size of the R&D exte...

The ordered arrays of quantum dots have been experimentally created recently. As a result there have been opened the possibility to fabricate and study the physical properties of superlattices consisting of quantum dots with different spatial shapes. The theory of quasiparticles (electron, hole and phonons) in such nanoheterosystems is developed only now [1]. In the proposed paper the influence...

INTRODUCTION Gene-set analysis (GSA) is an approach using the results of single-marker genome-wide association studies when investigating pathways as a whole with respect to the genetic basis of a disease. METHODS We performed a meta-analysis of seven GSAs for lung cancer, applying the method META-GSA. Overall, the information taken from 11,365 cases and 22,505 controls from within the TRICL/...

Geckos owe their remarkable stickiness to millions of dry, hard setae on their toes. In this study, we discovered that gecko setae stick more strongly the faster they slide, and do not wear out after 30,000 cycles. This is surprising because friction between dry, hard, macroscopic materials typically decreases at the onset of sliding, and as velocity increases, friction continues to decrease be...

High arsenic (As) content in the fertile delta plains of West Bengal has been widely reported since the 1990s. The shallow gray sand aquifers (GSA) deposited during the Holocene, are more commonly used as potable water sources, but they have high As levels. The release of As into groundwater is influenced by indigenous microbial communities metabolizing different organic carbon sources present ...

We report the largest and most comprehensive comparison of protein structural alignment methods. Specifically, we evaluate six publicly available structure alignment programs: SSAP, STRUCTAL, DALI, LSQMAN, CE and SSM by aligning all 8,581,970 protein structure pairs in a test set of 2930 protein domains specially selected from CATH v.2.4 to ensure sequence diversity. We consider an alignment go...

PURPOSE The Glaucoma Stereo Analysis Study (GSAS), a cross sectional multicenter collaborative study, used a stereo fundus camera to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients and investigated the relationships between these parameters and patient characteristics. SUBJECTS AND METHODS The study included 187 eyes of 187 subjects with primary open...