نتایج جستجو برای: guinea pig model
تعداد نتایج: 2158340 فیلتر نتایج به سال:
H9N2 avian influenza viruses circulate worldwide in poultry and have sporadically infected humans, raising concern whether H9N2 viruses have pandemic potential. Here, we use a guinea pig model to examine whether serial passage results in adaptive viral changes that confer a transmissible phenotype to a wild-type H9N2 virus. After nine serial passages of an H9N2 virus through guinea pigs, produc...
To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptibl...
in this study granulocyte-macrophage colony stimulating factor (csf) was prepared from rabbit and guinea pig lung tissues. the biological activity of these csfs was measured on semisolid agar culture and compared with those of mouse and rat. weight of animals, incubation time and cross-reactivity of csfs with different bone marrow sources were also investigated. the results showed that both rab...
The guinea pig (Cavea porcellus) is a mammalian non-rodent species in the Caviidae family. The sensitivity of the respiratory system and the susceptibility to infectious diseases allows the guinea pig to be a useful model for both infectious and non-infectious lung diseases such as asthma and tuberculosis. In this report, we demonstrated for the first time, the major cell types and composition ...
Guinea pigs are an alternative small animal model for many disease studies. Here we describe a pan-gd monoclonal antibody (anti-TCRd1) specific for the constant region of human T cell receptor delta chains that cross-reacts with a subpopulation of guinea pig (Cavia porcellus) lymphocytes. The phenotype and distribution of this subpopulation is consistent with the guinea pig gd T cell subset. FA...
Guinea pigs have been used as a second animal model to validate putative anti-chlamydial vaccine candidates tested in mice. However, the lack of guinea pig-specific reagents has limited the utility of this animal model in Chlamydia sp. vaccine studies. Using a novel guinea pig-specific transcriptome array, we determined correlates of protection in guinea pigs vaccinated with Chlamydia caviae (C...
BACKGROUND Allergic sensitization and reactions to guinea pig (Cavia porcellus) have been well documented in laboratory animal handlers, primarily manifesting as rhinitis, conjunctivitis, and asthma. Severe allergic reactions, however, are rare. METHODS We report two patients with severe allergic reactions following non-occupational exposure to guinea pigs. The first patient, an 11-year-old f...
Background: Adenosine receptors play an important role in the treatment of paroxysmal supraventricular tachycardia in cardiovascular system. This effect is through interaction with A1 type of G-protein-coupled adenosine receptors. The effect of N6-cyclopentyladenosine (CPA), an A1-selective adenosine agonist, was studied on ouabain-induced toxicity in spontaneously beating isolated guinea pig a...
To identify melanoma associated antigens (MAAs) shared by human and guinea pig melanoma cells, a battery of murine monoclonal antibodies (MoAbs) to human MAA and an antiserum to S100 protein were tested with four newly established guinea pig melanoma cell lines. Only the monoclonal antibodies 149.53 and 225.28 which recognize distinct determinants of the human high molecular weight-MAA (HMW-MAA...
Koffka's (1935, pp. 224-235) explanation of shape-constancy is based on the assumption of an invariant linkage between slant and shape. Koffka's hypothesis has been formulated in the following way by Beck and Gibson (1955): "A retinal projection of a given form determines a unique relation of apparent shape to apparent slant" (p. 126). The invariance hypothesis requires that perceived shape var...
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