BACKGROUND In addition to neurons, all components of the neurovascular unit (NVU), such as glial, endothelial, and basal membranes, are destroyed during traumatic brain injury (TBI). Previous studies have shown that excessive stimulation of calpain is crucial for cerebral injury after traumatic insult. The objective of this study was to investigate whether calpain activation participated in NVU...

Background: Gender differences in scientometric indicators among medical faculty members in Iran was investigated. Methods: The Research performance of the faculty at all universities and institutes of medical sciences in Iran was assessed using the Iranian Scientometric Information Database (ISID) on June 12, 2021. Selected variables in our study were name, gender, university, degree, academi...

BACKGROUND Patients with type 1 diabetes mellitus (DM) and renal hyperfiltration also exhibit systemic microvascular abnormalities, including endothelial dysfunction. The effect of renal hyperfiltration on systemic blood pressure (BP) is less clear. We therefore measured BP, renal hemodynamic function and circulating renin angiotensin aldosterone system (RAAS) mediators in type 1 DM patients wi...

background postprandial lipemia has been found to be strongly associated with atherosclerosis due to its atherogenic and thrombogenic lipoprotein changes. this phenomenon occurs even in normal subjects especially after high fat meals. orlistat, an anti- obesity drug, has been shown to address postprandial lipemia after a single high fat meal. objectives to compare the effects of orlistat and pl...

BACKGROUND Apigenin (4',5,7-trihydroxyflavone, AP), an active component of many medicinal Chinese herbs, exhibits anticancer properties in vitro and in vivo. This study aims to investigate the genotoxic, cytostatic, and cytotoxic effects of AP and time course changes in the levels of anti- and pro-apoptotic proteins involved in the DNA damage response in HepG2 cells. METHODS The genotoxic pot...

  Background and Objectives:  Helicobacter pylori cause a chronic gastric infection, and may cause extra gastrointestinal disease. The association between H. pylori infection and serum lipid profiles is still controversial. The aim of this study was to investigate any possible relationship between H. pylori infection and lipid levels. Materials and Methods: The subj...

Herein, graphene oxide is produced by electrochemical oxidation method from graphite rod to examine its hydrogen peroxide sensing ability. The electrochemically produced graphene oxide is characterized by SEM and XRD. A few layers of Graphene Oxide(GO) sheets and corrugations in graphene sheets appeared intensely crumpled and folded into a typical wrinkled structure after electrochemical oxidat...

Background and Aims: P504S (AMACR) is a mitochondrial enzyme expressed in renal cell carcinoma. Some of immunohistochemical markers in renal cell tumors are independent prognostic factor and show relation with histologic grading. AMACR expression increases with higher histological grading in different tumors; however, in RCC it is not obvious. In this study, we tried to investigate if ...