To understand the potential risk factors and protective factors for invasive Haemophilus influenzae type b (Hib) disease, we conducted a case-control study among Navajo children less than two years of age resident on the Navajo Nation. We analyzed household interview data for 60 cases that occurred between August 1988 and February 1991, and for 116 controls matched by age, gender, and geographi...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC) activity has been proposed to explain this resistance. Haemophilus influenzae frequently colonizes the airways of COPD patients, where it enhances inflammation. The effects of Haemophilus influenzae on HDAC activity have not been invest...

We present a case of fulminant neonatal sepsis caused by nontypable Haemophilus influenzae and discuss some potential prevention measures. A 33-year-old pregnant woman delivered a 1,166 g male neonate at 27 weeks and 2 days of gestation. He died 5 hours after birth. Haemophilus influenzae was isolated from the amniotic fluid, maternal vaginal discharge, placenta, neonatal oral cavity, neonatal ...

such as sepsis and meningitis, has declined substantially since the introduction of the H. influenzae serotype b vaccine. However, the H. influenzae type b vaccine fails to protect against nontypeable H. influenzae strains, which have become increasingly frequent causes of invasive disease, especially among children and the elderly. We summarize recent literature supporting the emergence of inv...

This is an author produced version of a paper published in Trends in Microbiology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. "Haemophilus influenzae and the complement system." Access to the published version may require journal subscription. Abstract The respiratory tract pathogen Haemophilus influenzae is responsible fo...

Streptococcus pneumoniae eta Haemophilus influenzae bakterio espezieek eragindako infekzioek prebalentzia handia dute, infekzio inbaditzaileek koadro larriak dakartzatelarik. Prebentziorako estrategia nagusia txertaketa da. Txerto pneumokoziko konjugatuak (PCV; ingelesezko sigla) b motako H. influenzae-ren (Hib) aurkako txertoak haurren txertaketa-egutegian ezarrita daude. polisakaridiko pneumo...