An experimentally simple sequential one-pot RuAAC reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields starting from an alkyl halide, sodium azide, and an alkyne, is reported. The organic azide is formed in situ by treating the primary alkyl halide with sodium azide in DMA under microwave heating. Subsequent addition of [RuClCp*(PPh(3))(2)] and the alkyne yielded...

One major synthetic route to the synthesis of benzyl amines, ethers, and esters is the nucleophilic substitution of a benzylic halide. To develop a method for the facile synthesis and functionalization of the isosteric azaborines, 2-chloromethyl-2,1-borazaronaphthalene has been synthesized in one step to afford a similar common precursor to a benzylic halide. This B-N isostere has been shown to...

When an alkyl halide is prepared from an alcohol and a hydrogen halide, protonation converts the LOH group into a good leaving group. However, if the alcohol molecule contains a group that might be sensitive to strongly acidic conditions, or if milder or even nonacidic conditions must be used for other reasons, different ways of converting the LOH group into a good leaving group are required. M...

The reduction of the charge of the species in molten salts, including the complete removal of the Coulomb interaction, appears to have the same eFect as an increase in the pressure on these systems. This observation leads to the prediction that a continuous pressure-induced structural change is to be found in the noble-metal halide melts at much lower pressures than those used to induce a simil...

Tropical rainforests have recently been confirmed to be the largest source of methyl chloride and a missing source for methyl bromide. However, very few field studies have quantified methyl halide emissions from tropical plants. This study presents the first methyl halide emission measurements from 16 tropical crop species at the University of California, Berkeley Botanical Gardens. Leaf vial e...

We have examined the effect of the myeloperoxidase-hydrogen peroxide-halide system and of activated human neutrophils on the ability of serum alpha 1-protease inhibitor (alpha 1-PI) to bind and inhibit porcine pancreatic elastase. Exposure to the isolated myeloperoxidase system resulted in nearly complete inactivation of alpha 1-PI. Inactivation was rapid (10 to 20 s); required active myelopero...

We investigated adenosine (Ado) activation of the cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo. A(2B) Ado receptors were identified in Calu-3, IB-3-1, COS-7, and primary human airway cells. Ado elevated cAMP in Calu-3, IB-3-1, and COS-7 cells and activated protein kinase A-dependent halide efflux in Calu-3 cells. Ado promoted arachidonic acid release from Calu...

We have developed a colloidal synthesis of nearly monodisperse nanocrystals of pure Cs4PbX6 (X = Cl, Br, I) and their mixed halide compositions with sizes ranging from 9 to 37 nm. The optical absorption spectra of these nanocrystals display a sharp, high energy peak due to transitions between states localized in individual PbX64- octahedra. These spectral features are insensitive to the size of...

The ̄uorescent and halide sensitive 6-methoxy-N-(3-sulfopropyl)quinolinium (SPQ) molecule has been synthesised and incorporated into a hydrophilic copolymer to produce a halide sensor ®lm. The sensor ®lm typically swells in aqueous media allowing dye ̄uorescence to be quenched by the diffusion of aqueous halide ions at high pH. The steady-state Stern±Volmer constants, KSV, for the sensor ®lm to...

The inhibition of the type-3 copper enzyme tyrosinase by halide ions was studied by kinetic and paramagnetic (1)H NMR methods. All halides are inhibitors in the conversion of l-3,4-dihydroxyphenylalanine (l-DOPA) with apparent inhibition constants that follow the order I(-) < F(-) << Cl(-) < Br(-) at pH 6.80. The results show that the inhibition arises from the interaction of halide with both t...