A series of 3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)pyridines (1a-j) were synthesized by Hantzsch method for pyridine synthesis. Treatment with chloroacetyl chloride produced N-(2-chloroacetyl)-3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)pyridines (2a-e), which on further treatment with sulfanilamide resulted in 3,5-(substituted)oxycarbonyl-...

The direct reductive amination of aromatic aldehydes has been achieved with excellent isolated yields (89-96%) using readily accessible Ph(3)PAuCl/AgOTf catalyst along with ethyl Hantzsch ester as hydrogen source under mild reaction conditions.

“I am indebted to Dr. (now Professor Sir Robert) Williams for bringing me into the team [The (British) PHLS Committee on Formaldehyde Disinfection] which investigated the use of formaldehyde for disinfecting fabrics. He gave me the job of finding a nontoxic neutralizing agent with which to treat infected fabric after exposure to formaldehyde vapour, in order that the bacterial viability results...

A novel green and efficient one-pot multicomponent reaction of dihydropyridine derivatives was reported as having good to excellent yield. In the presence of the catalyst ceric ammonium nitrate (CAN), different 1,3-diones and same starting materials as 5-bromothiophene-2-carboxaldehyde and ammonium acetate were used at room temperature under solvent-free condition for the Hantzsch pyridine synt...

A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.

Organic-inorganic hybrid materials provide a desirable platform for the development of novel functional materials. Here, we report one-pot synthesis mesoporous nanospheres by in-situ sol-gel condensation tetraethoxysilane around surfactant micelle-confined nano covalent organic polymer (nanoCOP) colloids. The containing nanoCOPs uniformly distributed in mesosilica network, inherited visible lig...