The essential oil isolated from fresh aerial parts of Hypericum perforatum L. was analyzed by GC and GC/MS. One hundred and thirty four identified compounds accounted for 98.7% of the total oil. The main components of the oil were: germacrene D (18.6%), (E)-caryophyllene (11.2%), 2-methyloctane (9.5%), α-pinene (6.5%), bicyclogermacrene (5.0%) and (E)-β-ocimene (4.6%). The volatile profile of H...

Background: Dermatophytes are the main cause of human superficial mycosis that is still a public health problem especially in tropical countries such as Iran. Objective: The aim of this study was determining the antifungal effect of Hypercom perforatum essential oil. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for the essential oil of the pl...

Medicinal and aromatic plants have popular recently to investigate their usability as natural resources in many areas due superior biological activity properties. Hypericum genus contained important medicinal plant species known worldwide. In this study, the ethanol extracts from different parts (flower, leaf stem) of three perforatum, heterophyllum, scabrum were screened for toxicity against a...

BACKGROUND The St John's Wort (Hypericum perforatum; Clusiaceae) has been used in traditional and modern medicine for a long time due to its high content of biologically active phenolics. The purpose of this work was to develop a method for their fractionation and identification, and to determine the most active antioxidant compounds in plant extract. RESULTS An LC-MS method which enables fas...

Two bioactive xanthones from Hypericum perforatum have been synthesized by direct routes. Benzo[c]xanthone 5 can be prepared from intermediate 4.

BACKGROUND Propolis and Hypericum perforatum L. are natural products which contain many active compounds and have numerous beneficial effects, including an antitumor effect. Gliobmastoma multiforme (GBM) is a common primary brain tumor with poor prognosis and limited treatment options. In this study, the effect of propolis (EEP) combined with H. perforatum L. (HPE) on glioblastoma cell line U87...

The purpose of this study was to investigate the effects of treatment with water, n-butanol and ether extracts of Hypercom perforatum L. on epileptogenesis in rabbits. Animals from the control group received solvent-ethanol, and the kindling model of epilepsy was used. Epileptic focus was induced in Chinchilla rabbits by stimulation of the hippocampus. The following parameters were determined: ...