New tools are needed to detect chronic sub-clinical mastitis, especially in automatic milking systems. Haptoglobin and serum amyloid A (SAA) are the two most sensitive bovine acute phase proteins, and their concentrations increase in milk from cows with clinical mastitis and in milk from cows with experimentally induced chronic sub-clinical Staphylococcus aureus mastitis. The aim of this study ...

BACKGROUND Ovarian cancer is the most lethal gynecologic disease due to delayed diagnosis, and ascites production is a characteristic of patients in advanced stages. The aim of this study was to perform the proteomic analysis of ascitic fluids of Mexican patients with ovarian carcinoma, in order to detect proteins with a differential expression pattern in the continuing search to identify bioma...

BACKGROUND Intravascular haemolysis has been associated with acute kidney injury (AKI) in different clinical settings (cardiac surgery, sickle cell disease). Haemolysis occurs frequently in critically ill burn patients. The aim of this study was to assess the predictive value of haptoglobin at admission to predict major adverse kidney events (MAKE) and AKI in critically ill burn patients. MET...

Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among plasma-protective proteins against oxidative damage caused by red blood cell rupture, haptoglobin and hemopexin are thought to play a crucial role. Haptoglobin and hemopexin, by binding with highaffinity hemoglobin and heme, respectively, exe...

We have found polymorphisms for the number of tandemly arranged haptoglobin-related (Hpr) genes in the haptoglobin gene cluster of Blacks. Genomic mapping and nucleotide sequence analysis indicate that two copies of the Hpr gene first resulted from unequal but homologous crossing-over in a region 3' to the haptoglobin (Hp) and the haptoglobin-related genes. Subsequent increases in the number of...

Aim: Determination of age-related changes in levels of some non-enzymatic antioxidants such as serum haptoglobin, haemoglobin and albumin, serum haptoglobin phenotype and serum protein profile was aimed with this study. Methods and results: Fifty Sprague-Dawley male rats were divided equally into five groups as 1 (one-month old), 2 (six-months old), 3 (twelve-months old), 4 (eighteen-months old...

ahaptoglobinemia is a common phenomenon in tropical countries,where it is probably due to malaria-induced haemolysis. previous studies have suggested that ahaptoglobinemia is more useful than the other parasite detection indexes to estimate the endemicity of malaria. the present study shows the relationship between malaria and haptoglobin, as a genetic marker in balouch population of sistan & b...

Delayed cerebral ischemia resulting from extracellular hemoglobin is an important determinant of outcome in subarachnoid hemorrhage. Hemoglobin is scavenged by the CD163-haptoglobin system in the circulation, but little is known about this scavenging pathway in the human CNS. The components of this system were analyzed in normal cerebrospinal fluid and after subarachnoid hemorrhage. The intrath...

hemolysis in patients exhibiting a concurrent acute-phase reaction as indicated by increases in C-reactive protein. The sensitivity of haptoglobin at a cutoff of 250 mgfL, however, is somewhat less than in situations where only hemolysis is present (2). Nonetheless, it is apparent that the decline in serum haptoglobin concentrations, owing to its complexing with hemoglobin and eventual removal ...

Associations between serum concentrations of haptoglobin, pathological lung lesions indicative of Mycoplasma hyopneumoniae (EP) or Actinobacillus pleuropneumoniae (PL) infection at slaughter and previous rearing environment were investigated in 510 pigs (90-100 kg live weight) from 17 farms in England. Haptoglobin concentrations were significantly higher in pigs showing pathological signs of EP...