Aim: To identify the quantity of haemoglobin (Hb) ‘S’(HbS), ‘A2’(HbA2), ‘F’(HbF) and other Hb phenotypes sickle cell anaemia (SCA) children in Enugu Nigeria using High Performance Liquid Chromatography(HPLC).
 Introduction: The inheritance two abnormal genes one which must be ‘S’ gene result Sickle disease (SCD). Co-inheritance S results homozygous SCD/SCA), coinheritance with ‘C’ gives Hb...

Thalassemia and thalassemic hemoglobinopathies pose serious health problem leading to severe morbidity and mortality in Indian population. Plethora of hemoglobin variants is prevalent in multiethnic Indian population. The aim of the present study was to analyze laboratory aspects, namely, hematological profile and HPLC findings of the hemoglobin variants detected, and to discuss problems that w...

One hundred ninety-seven children with sickle cell anemia were followed for 4 years at the Wayne State Comprehensive Sickle Cell Center to evaluate the stability of the hematological variables (Hb, Hct, RBC count, MCV, %HbF and %HBA2) over time. The mean values of the hematological measurements taken during three separate 16-month intervals were used to represent an individual's values. The cor...

remaining 161 cases with an HbA2 level ≤3.5% constituted the non-BTT group. In the BTT group 3 cases had concomitant iron deficiency. In the non-BTT group 120 cases had a serum ferritin level <15 ng/mL and were diagnosed as IDA; of the remaining 41cases, 12 had associated chronic illness indicative of ACD (anemia of chronic disease) and in the other 29 the cause of microcytosis could not be ide...

In this study. we carried out restriction endonuclease mapping in order to characterize the a-globin genotype of 10 Sardinian $#{176}-thalassemia heterozygotes, all of whom presented with normal red blood cell indices and increased HbA2 levels. In 8 of these subjects, we found the deletion of two a-globin genes ( -al -a), and in the remaining two the deletion of a single a-globin gene (-a/act)....

records, she was known to be a carrier of 5PN deficiency. The proposita’s hematological parameters were as follows: Hb: 10.7 g dL—1; Hct: 34%; RBC: 4.35 x 106; MCV: 77 fL; MCH: 24.7 pg; RDW: 16.2%; reticulocytes: 3.97%; ferritin: 30 (normal range=20-81ngr/Ml). Microscopic examination of a stained peripheral blood smear showed severe anisocytosis, microcytosis, and basophilic stippling. Biochemi...

Between January 1995 and December 2005, we conducted a screening program for the presence of Hb Neapolis, a rare abnormal Hb variant, in Campania, a region in Southern Italy. Nineteen patients with Hb Neapolis in heterozygosis and six patients with a genetic compound (Hb Neapolis/beta-thalassemia) were identified. Patients with Hb Neapolis in heterozygosis showed a slight alteration in HbA2 lev...

The continuation of a study of 24 dogs in the stages of avoidance reacquisition, differentiation training and generalization testing is reported. Subjects had previously received avoidance training with either response contingent CS termination on all trials or on only 50 percent of the training trials, prior to the administration of medial or lateral prefrontal lesions in 16 subjects. The rema...