Sorafenib is a breakthrough in the medical treatment aiming to control hepatocellular carcinoma (HCC) progression, but there some controversy patients' selection. The introduction of has led several positive effects. New more than promising antiangiogenic molecules have followed. Immunotherapy combined with therapy also strongly entered into HCC. All that induced significant guideline revision ...

Background: Hepatocellular carcinoma (HCC) is a major type of liver tumor. It represents up to 90% all malignancies. There are currently no reliable tumor markers or imaging technologies that can accurately diagnose early HCC. The use circulating micro-RNAs (miRNAs miR) as potential tool for detection HCC has become an emerging area study. Objectives: This study aimed evaluate the role miR-23b ...

According to the WHO’s recently released worldwide cancer data for 2020, liver ranks sixth in morbidity and third mortality among all malignancies. Hepatocellular carcinoma (HCC), most common kind of cancer, accounts approximately 80% primary malignancies is one leading causes death globally. The intractable tumor microenvironment plays an important role development progression HCC three major ...

IntroductionHepatocellular carcinoma (HCC) is the most common primary malignant tumor of liver.AimThis study aimed to assess serum hTERT level and its relation progression liver disease. Also, it effect HCV core protein on memory T-cells in patients with or without HCC, correlation between cells phenotype disease same patients.MethodsHTERT was assessed through relative quantitative RT-PCR. Flow...

Hepatocellular carcinoma (HCC) is a worldwide malignant tumor that caused irreversible consequences. Tanshinone IIA has been shown to play notable role in HCC treatment. However, the potential targets and associating mechanism of against remain unknown. We first screened out 105 overlapping genes by integrating predicted from multiple databases differentially expressed Cancer Genome Atlas (TCGA...

conclusions cd5l might be a useful biomarker for early diagnosis of hcc in hcv cirrhotic patients. lrg and hp α2 isoforms could be potential markers for distinguishing viral hcc. our results also further support the presence of varying molecules involved in hepatocarcinogenesis in hbv when compared with hcv infection. patients and methods two-dimensional polyacrylamide gel electrophoresis combi...

Abstract Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker its clinical significance We compared sFABP5 concentration patients with (HCC group) that hepatitis without (hepatitis group). Moreover, measured expression levels resected (...

Contrast-enhanced ultrasound (CEUS) and super-resolution (US) are novel technologies for differentiating hepatic masses including hepatocellular carcinoma (HCC). Kupffer-phase imaging on Sonazoid CEUS can increase the diagnostic sensitivity HCC, facilitates early identification treatment of HCC. On other hand, US depict intratumoral vascularity without contrast enhancement, its performance iden...

Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with 5-year survival rate of 10%, presenting extrahepatic metastases in 15–17% patients. HCC-bone represent approximately one-quarter all HCC metastases, most frequently the spine, pelvis, ribs, or femur. HCC-skull however, make up 0.4–1.6% HCC- bone metastases. Furthermore, solitary metastasis without known active primary a...