Background: Iron extra load is an anticipated and lethal consequence of chronic blood transfusion in major beta-thalassemia patients; therefore it is necessary to use an efficient iron chelator drug to stimulate the evacuation of the surplus iron from the body. This trial was performed to compare myocardial and hepatic magnetic resonance imaging T2 (MRI T2*) results of beta-thalassemia patients...

In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T1 or T2 contrast ability have been widely explored. The comprehensive investigation of high-performance MRI contr...

Introduction: Late enhanced-cardiac MRI using T1 contrast agent is known as the current standard of myocardial inflammation diagnosis. However, the poor sensitivity of late enhanced-cardiac MRI has hindered the reaching of a consensus on the clinical practice guidelines for its evaluation and treatment. In this study, we investigated whether T2 contrast agent-combined CMR (cardiac magnetic reso...

The relevance of cortical grey matter pathology in multiple sclerosis has become increasingly recognised over the past decade. Unfortunately, a large part of cortical lesions remain undetected on MRI using standard field strength. In vivo studies have shown improved detection by using higher magnetic field strengths up to 7 T. So far, a systematic histopathological verification of ultrahigh-fie...

BACKGROUND Magnetic resonance imaging (MRI) phantoms are routinely used for quality assurance in MRI centres; however their long term stability for verification of myocardial T1/ extracellular volume fraction (ECV) mapping has never been investigated. METHODS Nickel-chloride agarose gel phantoms were formulated in a reproducible laboratory procedure to mimic blood and myocardial T1 and T2 val...

BACKGROUND Myocardial fibrosis is a common hallmark of many diseases of the heart. Late gadolinium enhanced MRI is a powerful tool to image replacement fibrosis after myocardial infarction (MI). Interstitial fibrosis can be assessed indirectly from an extracellular volume fraction measurement using contrast-enhanced T1 mapping. Detection of short T2* species resulting from fibrotic tissue may p...

background access to appropriate images of fetal brain can greatly assist to diagnose of probable abnormalities. the aim of this study was to compare the suitability of t2-true fast imaging with steady state free precession (t2-trufi), and t2-half-fourier acquisition single-shot turbo spin-echo (t2- haste( magnetic resonance imaging (mri) to extract the fetal brain using the level set algorithm...