BACKGROUND The use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation. AIM To assess the efficacy of esomeprazole 20 and 40 mg for resolution of heartburn and acid regurgitation in continuous NSAIDs. METHODS A post hoc analysis of five clinical trials was performed. Two identically designed, pla...

BACKGROUND Oesophageal acid neutralization with antacids depends on the duration of oesophageal antacid exposure and acid neutralizing capacity. A gum that releases antacid as it is chewed could take advantage of both mechanisms to enhance heartburn relief. METHODS Twenty-four subjects were crossed over to four regimens: placebo, chewable antacid tablets (1000 mg CaCO3), lower dose gum (600 m...

INTRODUCTION Patients' socioeconomic status is rarely assessed during medical consultations. OBJECTIVE To correlate patients' socioeconomic conditions with symptoms of heartburn. METHODS 1184 patients who answered a questionnaire in three cities on the coast of the State of Sä Paulo, Brazil, were evaluated prospectively. Socioeconomic status was assessed using several criteria: number of ba...

138. 9. Guda N, Partington S, Vakil N. Symptomatic gastrooesophageal reflux, arousals and sleep quality in patients undergoing polysomnography for possible obstructive sleep apnoea. Aliment Pharm Ther. 2004;20:1153-1159.Indeed, results of a recent Internet survey showed thatGERD-related symptom severity was strongly associatedwith work impairment, and that nighttime GERD wasasso...

previous studies have reported the efficacy of baclofen in the treatment of gastroesophageal reflux diseases (gerd). the objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained release baclofen (sr baclofen) vs omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of gerd. a prospective, double blind, place...

Background: Dyspepsia and heartburn are among the most frequent complaints of the upper gastrointestinal tract impacting quality of life. The present study aimed to investigate the impact of drinking a natural mineral water (medicinal product category “Heilwasser” in Germany) high in hydrogen carbonate (Staatl. Fachingen STILL) on functional dyspeptic complaints and heartburn. Methods: 56 men a...