te Boxmeer. Chapter Title 1) General introduction 2) Evolution and diversity of prokaryotic small heat shock proteins 3) Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9 4) The human genome encodes ten α-crystallin-related small heat shock proteins: HspB1-10 5) Tsp36, a tapeworm small heat shock protein with a duplicated α-cry...

Previously, we showed that mild heat shock modulates patterns of cell death in response to glucose deprivation (GD), a common characteristic of the tumor microenvironment, by switching necrosis to apoptosis through ERK-dependent suppression of reactive oxygen species production in A549 cells. In the present study, we further examined the molecular mechanism underlying mild heat shock-induced ne...

Luo, Guangju, Xiaoyan Sun, Eric Hungness, and PerOlof Hasselgren. Heat shock protects L6 myotubes from catabolic effects of dexamethasone and prevents downregulation of NF-kB. Am J Physiol Regulatory Integrative Comp Physiol 281: R1193–R1200, 2001.—Glucocorticoids are the most important mediator of muscle cachexia in various catabolic conditions. Recent studies suggest that the transcription fa...

The Escherichia coli DnaK heat shock protein has been identified previously as a negative regulator of E. coli heat shock gene expression. We report that two other heat shock proteins, DnaJ and GrpE, are also involved in the negative regulation of heat shock gene expression. Strains carrying defective dnaK, dnaj, or grpE alleles have enhanced synthesis of heat shock proteins at low temperature ...