This study was carried out to optimize the various approaches analyze effects of variables on total flavonoid content extraction from roots Helicteres hirsuta L. The existence compounds in methanol fraction accessed by using LC-MS/MS analysis. results identified ideal parameters such as times (30 minutes); solvent concentration (50%); ultrasonic frequency (12 Hz); and material/solvent ratio [1:...

Colorectal cancer (CRC) is one of the most common malignancies and most frequent cause of cancer death worldwide. The activation of both NF-κB and STAT3 signaling and the crosstalk between them play an important role in colorectal tumor. Helicteres angustifolia L. is a type of commonly used Chinese medicinal herb and possesses a wide variety of biological activities. In the present study, we in...