Binary combinations of the N-nucleoside ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) and the C-nucleoside analog selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide) or tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) were tested in vitro for activity against Venezuelan equine encephalomyelitis, Japanese encephalitis, yellow fever, Rift Valley fever, Korean...

The increasing cases of Dengue Hemorrhagic Fever in all regions Indonesia are a disease transmitted through vector amid the ongoing COVID-19 Pandemic, which can seriously threaten public health. This study aims to analyze relationship between thrombocytopenia patients with and dengue hemorrhagic fever. research was conducted from February March 2022. tools used this were Abbot Cell-Dyn Ruby Hem...

BACKGROUND Crimean-Congo hemorrhagic fever was rarely reported from Iran before 1999. In a recent outbreak, the disease has been reported from different provinces of Iran, especially from Sistan and Baluchestan. Ribavirin has been recommended by World Health Organization as a potential therapeutic modality for Crimean-Congo hemorrhagic fever. This study was conducted to determine the clinical o...

crimean- congo hemorrhagic fever (cchf) is a viral zoonotic tick-born disease with a mortality rate of up to 50% in humans. after a short incubation period, the disease is characterized by sudden fever, chills, severe headache, dizziness, back, and abdominal pain. additional symptoms can include nausea, vomiting, diarrhea, neuropsychiatric, and cardiovascular changes. in severe cases, hemorrhag...

crimean-congo hemorrhagic fever: treatment and control strategy in admitted patients

Hemorrhagic fever with renal syndrome (HFRS) is a serious human disease of zoonotic viral origin. A group of different viruses that belong to the family of hemorrhagic fever could represent with HFRS. The basic pathophysiologic feature is virus-induced leaky microcirculation. There is no effective antiviral treatment against them. Because of rapid environmental changes, global warming, and incr...

We report a case of toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. A healthy 20-year-old male soldier presented with confluent purpuric and erythematous dusky red macules evolving to flaccid blister and epidermal detachment on the whole body with conjunctival injection. The patient had no antecedent medical or surgical conditi...

Letters No special nursing precautions were taken either during the hospitalization or after the death, and the body was transferred to Kikwit to be buried. On April 30, another nun who took care of the index patient during the night of April 23 became ill with fever, headache, and myalgia. Over the next few days, the second patient had a clinical picture identical to that of the index patient,...

In this review of studies on the hemorrhagic fevers of Southern Africa carried out in the South African Institute for Medical Research, attention has been called to occurrence of meningococcal septicemia in recruits to the mining industry and South African Army, to cases of staphylococcal and streptococcal septicemia with hemorrhagic manifestations, and to the occurrence of plague which, in its...