Because liver involvement in patients with metastatic cancer has limited options and poor outcomes, we conducted a phase I study to determine the safety, activity, and pharmacokinetic characteristics of hepatic arterial infusion of nanoparticle albumin-bound paclitaxel (HAI nab-paclitaxel). Cohorts of three patients having predominant hepatic metastases received HAI nab-paclitaxel at three dose...

primary hepatic lymphoma (phl) was a rare malignancy usually presenting with abdominal pain, malaise, hepatomegaly, b-symptoms, fatigue, nausea, vomiting and jaundice. it mostly involves liver without any palpable lymphadenopathy and leukemia in peripheral blood smear. on july 22, 2014, a 64 year old man presented with abdominal pain localizing in right upper quadrant and fullness from 2 years ...

a 34-year-old hiv positive-man was admitted to the hospital due to fever and abdominal pain. constant and generalized abdominal pain started 3 months prior to admission (pta) in upper quadrants of abdomen followed by mild odynophagia, early satiety and more than 20 kg weight loss since then. intermittent fever begun 7 days pta and cough, sputum and dyspnea started since 5 days pta. his general ...

Introduction. There has been limited information reported on the use of hepatic arterial therapy in liver dominant hepatic metastases arising from lung cancer. The aim of this study was to evaluate the safety and efficacy of hepatic arterial therapy in the treatment of liver dominant hepatic metastases arising from lung cancer. Methods. Thirteen patients underwent a total of 30 treatment sessio...

To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signat...

A 66-year-old man with postsigmoidectomy status for colon cancer received laparoscopic partial hepatectomy due to a hepatic mass with employing titanium clips were for a vascular clamp. Histological examination showed liver metastasis from sigmoid colon cancer. Twenty-nine months after the partial hepatectomy, a mass developed on the stump at the hepatic resection. Laparoscopic left lateral seg...

Testicular cancer is the most common type of cancer among young patients. At the moment of diagnosis, between 30% and 50% of them have developed metastases, which affect retroperitoneal lymph nodes and lungs especially. Hepatic compromise is rare and is associated with poor prognosis. Besides this, hepatic lesions can complicate with necrosis and overgrowth, a phenomenon that is mainly seen in ...

Colorectal cancer (CRC) is the fourth most common malignancy in the United States (1). Approximately 130,000 new patients will be diagnosed with this cancer in 1999. It is the second leading cause of cancer death, with 55,000 patients expected to die of it. Most patients die of metastatic disease. The vast majority of them have liver as the dominant site of metastases (2). Approximately 30% of ...

Solitary pancreatic metastasis of esophageal cancer is extremely rare. We report the case of a 58-year-old male admitted with esophageal cancer. Additional asymptomatic solitary hepatic and pancreatic masses were observed in the staging work-up for esophageal cancer. The hepatic mass was confirmed as a primary hepatocellular carcinoma with an ultrasound-guided needle biopsy. An esophagectomy wi...

The right hepatic artery usually branches from the common hepatic artery, however, there are cases showing anatomic variations. We present 41-year-old female patient with gallbladder cancer. In this case, the accessory right hepatic artery branched from the gastroduodenal artery, passed in front of the common bile duct and fed into the anterior segment of the liver. Cholecystectomy and resectio...