BACKGROUND High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 have been identified as novel antigens of perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCAs), and the existence of anti-HMG1 and anti-HMG2 antibodies in a population of patients with ulcerative colitis has been reported. AIMS To investigate whether HMG1 and HMG2 are target antigens for p-ANCAs in aut...

Hepatitis B virus (HBV) infection remains a global challenge, although there is currently a safe and effective vaccine available. HBV prevalence in Ghana is not well documented, but vary regionally from 4.8% to 12.3% in the general population, 10.8% to 12.7% in blood donors and about 10.6% in pregnant women. This puts Ghana among the high endemic countries in Africa. The study objective was to ...

High viral and/or antigen load may be an important cause of the T cell hyporesponsiveness to hepatitis B virus (HBV) antigens that is often observed in patients with chronic HBV infection. Reduction of viral and antigen load by lamivudine treatment represents an ideal model for investigating this hypothesis. HLA class II restricted T cell responses and serum levels of HBV-DNA, HBsAg, and HBeAg ...

occult hbv infection of hemodialysis (hd) patients is informative in terms of virus transmission. it may be of clinical importance in hd patients. the aim of this study was to investigate the prevalence of anti-hbc in the hd patients. number of 126 patients undergoing hemodialysis were included in this study from main hemodialysis units in yazd. hepatitis b surface antigens (hbsag), hepatitis b...

BACKGROUND AND OBJECTIVES Hepatocellular carcinoma (HCC) is often associated with chronic hepatitis due to hepatitis-B or -C viruses. Active specific immunotherapy (ASI) with autologous dendritic cells (DC) presenting antigens from autologous tumor stem cell (TC) lines is associated with promising long-term survival in metastatic cancer, but hepatitis patients were excluded. ASI might benefit h...

Two human hypatitis viruses have been identified and characterized, but one or more additional agents exist. Hepatitis B virus (HBV) is a complex 42-nm predominantly double-stranded DNA virus with distinct surface and core antigens and an endogenous DNA polymerase. Hepatitis A virus (HAV) is a 27-nm RNA virus with enterovirus-like properties. Progressively more sensitive and specific immunologi...

Hepatitis is a disorder in liver inflammation that can be caused by infection with parasites, protozoa, bacteria, viruses, metabolic disorders, drugs, and alcohol causes damage to human cells attack all ages, genders, races throughout the world. Serum Glutamic Oxaloacetic Transaminase (SGOT) Pyruvic (SGPT) levels EDTA plasma tend increase more than serum. It because contains coagulation factors...

background and aims: hepatitis d virus (hdv) can infect human population either as a superinfection or concurrent hepatitis b virus (hbv) infection. it is expected that presence of hdv infection is more prevalent in endemic hbv areas. overall 5% of iranian general populations are chronic hbv carriers. the aim of this study was to determine the seroprevalence of hdv and its clinical impact in a ...