Girdin has been proven to play a vital role in the process of proliferation, apoptosis, and invasion in various cancer cells, yet the underlying molecular mechanism in primary hepatocellular carcinoma (HCC) has not yet been clarified. Thereafter, we performed immunohistochemistry to detect the expression of Girdin in 40 primary HCC tissues and 30 matched adjacent tissues using hepatic carcinoma...

Increasing evidence shows that liver tumor-initiating cells (T-ICs) closely associated with the progression, metastasis, recurrence and chemo-resistance of hepatocellular carcinoma (HCC). However, underlying mechanism for propagation T-ICs remains unclear. Here we show miR-361-3p is upregulated in T-ICs. Knockdown impairs self-renewal tumorigenicity Conversely, forced expression enhances Mechan...

Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality. At present, diagnostic methods such as imaging observation, serum testing tissue biopsy, well treatment surgical resection, radiotherapy, chemotherapy have certain limitations in clinical interventions for HCC due to the complex pathogenesis drug resistance of liver cancer, which seriously affect survival pro...

Hepatocellular carcinoma (HCC) remains a major problem in oncology. The molecular mechanisms which underlie its pathogenesis are poorly understood. Recently the Small Heterodimer Partner (SHP), an orphan nuclear receptor, was suggested to be involved as a tumor suppressor in hepatocellular carcinoma development. To date, there are no such studies regarding fibrolamellar carcinoma, a less common...

Hepatocellular carcinoma (HCC), the most common primary liver cancer, relies on formation of new blood vessel for growth and frequent intrahepatic extrahepatic metastasis. Therefore, it is important to explore underlying molecular mechanisms tumor angiogenesis HCC. Recently, microRNAs have been shown modulate angiogenic processes by modulating expression critical factors. However, potential rol...

BACKGROUND MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese Medicine. In light of the important role of miRNAs in hepatocellular carcinoma, we questioned whether the inhibitory effects of ESC on hepatocellular carcinoma (HCC) were asso...

The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell f...

Sonazoid, a second-generation ultrasound contrast agent, was introduced for the diagnosis of hepatic nodules. To clarify issues with Sonazoid contrast-enhanced ultrasonography hepatocellular carcinoma (HCC), Korean Society Radiology and Abdominal collaborated on guidelines. The guidelines are de novo, evidence-based, selected using an electronic voting system consensus. These include imaging pr...

Abstract Aim Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in background of chronic disease and prolonged inflammation. A major contributor the complex molecular pathogenesis HCC highly intertwined cross-talk between tumor surrounding stromal cells, such as hepatic stellate endothelial macrophages other immune cells. These tumor-stroma interactions actively fuel...

Background: Hepatocellular carcinoma (HCC) is the fifth most common malignancy in world. Surgical intervention remains primary treatment option for resectable liver cancer. However, low curative resection ratio, high metastatic and risk of recurrence make this less than ideal. Additionally, choice transplantation limited by availability donors. This literature review aimed to discuss combinatio...