Natural products are the best source for various medicinal drugs. Regardless investigate the toxic effect of these plant extracts, the results will still unsafe and unacceptable. This study aimed to identify anti-cancer activity and cytotoxicity effect of Momordica charantia extract on different cancer cell line. Materials and Methods:to archive the aim of this study 3 different cancer cell lin...

Garcinia dulcis or locally known in Malaysia as "mundu" belongs to the family of Clusiaceae. The study was conducted to investigate the anticancer potential of different parts of G. dulcis fruit extracts and their possible mechanism of action in HepG2 liver cancer cell line. MTT assay showed that the peel, flesh, and seed extracts of G. dulcis induced cytotoxicity in HepG2 cell line with IC50 v...

Cleistocactus winteri is a succulent plant of the Cactaceae family, commonly known as the golden rat tail. Many members of the Cactaceae family are the focus of chemical and biological studies as they contain bioactive compounds, well known for their health-related properties. We aimed to investigate Cleistocactus winteri stems both phytochemically and biologicallyfor the firs...

toxicity bioassays are important tools to determine biological effects of chemical agents on species. the questions remained on, what effects have been imposed on each of the different molecular site of cells by chemical exposure and how to find a pattern for chemical toxicity. to address the questions, hepg2 cell lines were exposed to the different concentrations of cisplatin for 24 hours to r...

shiga toxins (stxs) are bacterial virulence factors produced by shigella dysenteriae serotype 1 and escherichia coli strains. stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. additionally, stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. the inflammatory cyto...

To investigate the antiproliferative / cytotoxicity effect of methanolic fruit extract of Cucurbita digitata on human hepatocellular carcinoma HepG2 cell line. Cytotoxicity tests on HepG2 liver cancer cell lines were performed by Caspase assay, Flow cytometry and DNA fragmentation assays. Cell proliferations measured by Caspase assay exhibited significant inhibition of cell growth with an incre...

Two new bisindole alkaloids, 12?-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 2), were isolated from the leaves of Voacanga grandifolia, together with two known alkaloids. Their structures elucidated on basis 1D 2D NMR data. 1 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 very low cytotoxic a human cell line, HepG2 cells.

Background: Various medicinal plants have much efficacious value as treatment of many fatal conditions including cancer. Kigelia africana has known therapeutic efficacy in different ailments and been used traditional medicine since ages. Aim: To evaluate anticancer property any drug or plant extract HepG2 cell line. Methodology: Anticancer activity n-hexane ethanolic extracts was checked. IC50 ...