In this paper, we aim to investigate strong herb-herb interactions in TCM for effective treatment of insomnia. Given that extraction of herb interactions is quite similar to gene epistasis study due to non-linear interactions among their study factors, we propose to apply Multifactor Dimensionality Reduction (MDR) that has shown useful in discovering hidden interaction patterns in biomedical do...

The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical characteristics to the human small intestine. The FDA recommends this model as integral component of the Biopharmaceutics Classification System (BCS). Most dedicated laboratori...

Controlled clinical studies are needed to clarify and determine the clinical importance of drug-herb interactions. However, it is unlikely that this information will be forthcoming except as anecdotal reports. Patients taking drugs with a narrow therapeutic index (cyclosporine, digoxin, hypoglycemic agents, lithium, phenytoin, procainamide, theophylline, tricyclic antidepressants, and warfarin)...

Epimedium sagittatum (Sieb. et Zucc.) Maxim is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction in Western Medicine. This study evaluates the herbal-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil in rats by ultra-performance liquid chromato...

OBJECTIVE Tinospora cordifolia is used for treatment of several diseases in Indian system of medicine. In the present study, the inhibition potential of T. cordifolia extracts and its constituent tinosporaside to cause herb-drug interactions through rat and human liver cytochrome enzymes was evaluated. MATERIALS AND METHODS Bioactive compound was quantified through reverse phase high-performa...

The extent of herb-drug interactions (H-DIs) is still largely unknown, although the use of herbal medicines among the general public is increasing. The theoretical and clinical evidence for some important H-DIs is presented, together with an explanation of pharmacodynamic interactions and pharmacokinetic effects involving P-glycoprotein and cytochrome P450 enzymes. Currently, research is being ...

1. Morin, a natural flavonol, is present in many plants. It has anti-inflammatory and immunomodulatory activities often used as an adjuvant treatment for arthritis. Diclofenac sodium the first-choice drug of rheumatoid However, herb-drug interaction (HDI) between morin diclofenac remains unclear.2. The aim research was to investigate whether how affect pharmacokinetic profile sodium.3. enzyme k...

The consumption of Chinese herbal medicines (CHMs) is increasing exponentially. Many patients utilize CHMs concomitantly with prescription drugs in great frequency. Herb-drug interaction has hence become an important focus of study. Transporter-mediated herb-drug interactions have the potential to seriously influence drug efficacy and toxicity. Since organic anion transporter 1 (OAT1) is crucia...