background: in northeastern iran there is an area of high incidence of esophageal cancer which is populated by residents of turkmen ancestry. several environmental risk factors for esophageal cancer have been proposed, but the roles of familial and genetic factors have not been studied extensively in the turkmen population. materials and methods: we evaluated the importance of familial risk fac...

We examined the influence of D177N (D178N in humans) mutation on the conformational stability of the S2 region of moPrP(C) with varying pHs by using the SDSL-ESR technique. The ESR spectrum of D177N at pH 7.5 was narrower than that of Y161R1, referred to as WT( *). The ESR spectrum of D177N did not change when pH in the solution decreased to pH 4.0. Our results suggested that the disappearance ...

Cicerone and Di Stefano defined studied the class of k-distance-hereditary graphs, i.e., graphs where distance in each connected induced subgraph is at most k times whole graph. The represent a generalization well known distance-hereditary which actually correspond to 1-distance-hereditary graphs. In this paper we make step forward study these new by providing characterizations for all such tha...

The paper addresses a kind of non-autonomous nonlocal parabolic equations when the external force contains hereditary characteristics involving bounded and unbounded delays. First, well-posedness problem is analyzed by Galerkin method energy estimations in phase space C ? ( X ) . Moreover, some results related to strong solutions are proved under suitable assumptions. existence stationary then ...

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia and severe, recurrent epistaxis is a common clinical phenotype associated with HHT. An intranasal treatment regime of diluted AvastinTM (Bevacizumab; recombinant humanized anti-vascular epithelial growth factor immunoglobin G1) using a pulsatile nasal irrigator has proven efficacious in clinical practice. Ho...

It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular basis of genomic instability in cancer is still partially understood. The observation that hereditary cancers are often characterized by mutations in DNA repair and checkpoint genes suggests that accumulation of DNA damage is a major contrib...

A variant of glucose-6-phosphate-dehyelectrophoretic mobility (B), and utilizadrogenase deficiency associated with tion of substrate analogues 2-deoxy-G6P chronic hereditary hemolytic anemia was and deamino-NADP were normal. The discovered in a 9-yr-old white male. The activity of G6PD in the leukocytes and erythrocytes contained 5% of normal platelets was 15% and 28% of normal enzyme activity,...