The genetic component of colorectal cancer (CRC) predisposition has been only partially explained. We recently suggested that a subtle decrease in the expression of one allele of the TGFBR1 gene was a heritable quantitative trait predisposing to CRC. Here, we refined the measurements of allele-specific expression (ASE) of TGFBR1 in a population-based series of CRC patients and controls. Five si...

We describe in this study a reliable method for the breeding of the Watanabe heritable hyperlipidemic (WHHL) rabbit. Placing a male and a female WHHL rabbit in the same cage for the purpose of mating resulted in only two pregnancies out of a total of 227 mating attempts (0.9%). After manually assisting the rabbits, 15% of the matings resulted in pregnancies. When the female rabbits were injecte...

Maternally transmitted bacteria have been important players in the evolution of insects and other arthropods, affecting their nutrition, defense, development, and reproduction. Wolbachia are the best studied among these and typically the most prevalent. While several other bacteria have independently evolved a heritable lifestyle, less is known about their host ranges. Moreover, most groups of ...

Although genetic factors underpin individual differences in religiosity, the psychological mechanisms through which such influences are manifested are presently unknown. Religiosity is associated with concerns for community integration and existential certainty, suggesting that heritable influences underlying such sentiments may overlap with heritable influences underpinning religiosity. Here w...

The genetic basis of individual differences in attitudes was examined in a survey of 195 pairs of monozygotic twins and 141 pairs of same-sex dizygotic twins. A principal components analysis of the 30 attitude items in the survey identified 9 attitude factors, of which 6 yielded significant heritability coefficients. Nonshared environmental factors accounted for the most variance in the attitud...

Patients with heritable and idiopathic PVOD have few therapeutic options. On suspicion of immune dysregulation, methylprednisolone or oral prednisolone then mycophenolate mofetil was trialled in three cases, resulting clinical improvement/stability.https://bit.ly/376mwR9

How are retrospective accounts of family rearing environments linked to adult personality? We addressed this question by measuring both domains in a sample of 180 reared-apart twins. Twins completed extensive measures of rearing environments (the Minnesota-Briggs History Record, the Block Environmental Questionnaire, the Family Environment Scale, and the Physical Facilities Questionnaire) and a...