نتایج جستجو برای: hesi
تعداد نتایج: 107 فیلتر نتایج به سال:
BACKGROUND There is a recognized need to improve the application of epidemiologic data in human health risk assessment especially for understanding and characterizing risks from environmental and occupational exposures. Although there is uncertainty associated with the results of most epidemiologic studies, techniques exist to characterize uncertainty that can be applied to improve weight-of-ev...
The HESI-led RISK21 effort has developed a framework supporting the use of twenty-first century technology in obtaining and using information for chemical risk assessment. This framework represents a problem formulation-based, exposure-driven, tiered data acquisition approach that leads to an informed decision on human health safety to be made when sufficient evidence is available. It provides ...
In 2003 members of IlSI – HeSI started a project called ACSA (agrochemical safety assessment). the purpose of this project was to evaluate how toxicity testing for agrochemicals could be done if the testing requirements were to be designed from scratch. the background of this question was the notion that our society continues to add testing requirements to an already substantial package without...
A rapid, sensitive, and specific ultra-high-performance liquid chromatography with heated electrospray ionization-tandem mass spectrometry (UHPLC-HESI-MS-MS) method to detect and quantify glycopyrrolate in horse plasma has been developed and validated. We also determined glycopyrrolate in plasma after oral and intravenous administration of clinically relevant doses to Thoroughbred horses. Cali...
A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoin...
The photocatalytic degradation of sulfonamides in aqueous TiO2 suspension under UV irradiation has been investigated using potassium ferrate as electron acceptors. The results showed that the stability of Fe(VI) is dependent on pH significantly, and the stability reduces obviously in the presence of UV-TiO2. The experiments indicated that Fe(VI) could effectively scavenge the conduction band el...
Mass spectrometry has become a method of choice to characterize bioactive compounds in biological samples because of its sensitivity and selectivity. Hybrid ultra-HPLC hyphenated with Orbitrap mass analyzer is an innovative state of the art technology that allows fast and accurate metabolomic analyses. In this work the metabolites of a Chilean mistletoe endemic to the VIII region of Chile were ...
Backgrounds: Oxytocin is nowadays used to increase the agricultural products besides its use during milking of cattle leading contamination produce and milk with oxytocin. Monitoring accurate oxytocin contaminations from foodstuffs sometimes required maintain quality standard. The commonly assays in this study were interfered by food matrix. There a need develop an confirmed method for monitori...
Apiaceae plants are multipurpose folk remedies and bioactive foods that show a remarkable ability to biosynthesize large number of secondary metabolites with antitumor chemopreventive potential. Among the various members Apiaceae, celery (Apium graveolens L.) has long been used as popular edible medicinal plant owing its plentiful health benefits nutraceutical properties; however, anticancer po...
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