Selected flavonoids that are known as inducers and a suppressor of nodulation (nod) genes of the symbiotic bacterium Rhizobium leguminosarum bv. viciae were tested for their effect on symbiosis formation with garden pea as the host. A solid substrate was omitted from the hydroponic growing system in order to prevent losses of flavonoids due to adsorption and degradation. The presumed interactio...

The color of sweet cherry fruits is an important indicator their appearance and quality. That influences the purchasing desires consumers. We performed a multi-omics analysis two different colors (yellow “Bing Hu” dark-red “Hong Deng” fruits). A total 12 flavonoid differential metabolites, including hesperetin, rutin, quercetin, 18 structural genes, PAL, CHS, FLS, DFR, were identified. Possible...

A one-pot, 2-step flow bioprocess for the obtainment of hesperetin (HP) and quercetin (Q) aglycones from hesperidin (HES) rutin (RT), has been developed, employing a co-immobilized preparation α-rhamnosidase (RN) β-glycosidase (HOR).

Background The pathophysiology of neurodegenerative diseases, particularly Alzheimer’s disease is multifactorial. However, with scientific evidences suggesting that various antioxidants possess different protective mechanisms, thus hypothetically/theoretically no single natural compound can adequately abrogate these plethora cascades. Hence, there a need for paradigm shift from the usual monoth...

BACKGROUND Polyphenols are phytochemicals that possess antioxidant and anti-inflammatory properties and improve glucose metabolism in animal experiments, although data from prospective epidemiologic studies examining polyphenol intakes in relation to type 2 diabetes (T2D) risk are inconsistent. OBJECTIVES We examined urinary excretion of select flavonoid and phenolic acid metabolites, as biom...

Flavonoids are a group of polyphenolic compounds ubiquitous in many plants including fruits, vegetables, nuts, seeds, grains, tea and wine (Hollman & Katan, 1999). Flavonoids belong to two classes i) Flavanones and ii) Flavones. The most common flavanones are hesperetin from oranges and naringenin from grapefruit. The most common flavones, also known as polymethoxylated flavones, are tangeretin...

The purpose of this study was to explore the potential formulating hesperetin into an ophthalmic solution with dipotassium glycyrrhizinate (DG) as a micelle nanocarrier. A DG-based encapsulating (DG-Hes) developed and its in vitro/in vivo characterizations were evaluated. optimal formulation featured DG/hesperetin (Hes) weight ratio 12:1 encapsulation efficiency 90.4 ± 1.7%; optimized DG-Hes ch...