Heteroresistance refers to the presence, within a larger population of fully antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibility. This phenomenon has been described in a wide range of microorganisms, but much recent attention has been directed toward its expression in Staphylococcus aureus. Although it has long been known that resistance to methicillin is char...

Abstract Background Heteroresistance is a phenotype in which clinically susceptible bacterial isolate contains less subpopulations. Unexpectedly high levels of treatment failure for cefiderocol, novel antibiotic designed to treat multidrug-resistant infections, have been attributed this phenomenon. Objectives To determine prevalence cefiderocol heteroresistance amongst clinical isolates at Nort...

12 *Corresponding author. Mailing address: Laboratory of Clinical Infectious Diseases, 13 National Institute of Allergy and Infectious Diseases, National Institutes of Health, 14 Bethesda, MD 20892. Phone: (301) 496-1602. Fax: (301) 480-3458. 15 E-mail: [email protected] 16 17 18 Running head: Heteroresistance in C. neoformans 19 Copyright © 2009, American Society for Microbiology and/or ...

We disagree with the conclusions presented by Jacob E Choby and coworkers1Choby JE Ozturk T Satola SW JT Weiss DS Widespread cefiderocol heteroresistance in carbapenem-resistant Gram-negative pathogens.Lancet Infect Dis. 2021; 21: 597-598Summary Full Text PDF PubMed Scopus (5) Google Scholar their Correspondence, which they postulated a causal link between in-vitro observation of to bacteria im...