The synthesis of methyl 3,3-bis[4-(dimethylamino)phenyl]-2,2-dimethylpropanoate is achieved by means the alkylation isobutyrate silyl enol ether with bis[4-(dimethylamino)phenyl]methanol, facilitated using 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent and reaction promoter. proceeds smoothly to produce mentioned compound in good yield via metal additive-free procedure. corresponding est...

Abstract. The reliable detection of subsurface ice using non-destructive geophysical methods is an important objective in permafrost research. content the frozen ground essential parameter for further interpretation, example terms risk analysis and description carbon feedback by thawing processes. high-frequency induced polarization method (HFIP) enables measurement frequency-dependent electric...

Multidimensional solution NMR spectroscopic techniques have been used to obtain atomic level information about a recombinant spider silk construct in hexafluoro-isopropanol (HFIP). The synthetic 49 kDa silk-like protein mimics authentic silk from Nephila clavipes, with the inclusion of an extracellular matrix recognition motif. 2D (1)H-(15)N HSQC NMR spectroscopy reveals 33 cross peaks, which w...

Silk fibroin is a potent alternative to other biodegradable biopolymers for bone tissue engineering (TE), because of its tunable architecture and mechanical properties, and its demonstrated ability to support bone formation both in vitro and in vivo. In this study, we investigated a range of silk scaffolds for bone TE using human adipose-derived stem cells (hASCs), an attractive cell source for...

Retention data for a set of 69 compounds using rapid gradient elution are obtained on a wide range of reversed-phase stationary phases and organic modifiers. The chromatographic stationary phases studied are Inertsil (IN)-ODS, pentafluorophenyl, fluoro-octyl, n-propylcyano, Polymer (PLRP-S 100), and hexylphenyl. The organic solvent modifiers are 2,2,2-trifluoroethanol (TFE); 1,1,1,3,3,3-hexaflu...

Described herein is a divergent continuous-flow approach for the biomimetic oxidative cyclization of reticuline-type alkaloids to aporphine and morphinandienone natural products using hypervalent iodine(III) reagents. The method was based on detailed knowledge reaction mechanisms in order develop robust conditions toward selective synthesis either or products. In this frame, we exploited abilit...