Time-varying interactions of human fetal osteoblastic cells (hFOB 1.19) with materials of diverse chemical composition and surface energy, including biodegradable lactide/glycolide-based polymers, were assessed using a combination of assays sensitive to different phases of cell-substratum compatibility. Short-term (minutes to hours) cell-attachment-rate assays were used to measure the earliest ...

background: endometriosis is a complex disorder in reproductive age women which consist of stromal and epithelial cells implantation outside the uterine cavity. adiponectin is a member of cytokine family with various metabolic roles and proliferation inhibition of many cancer cells. the aim of the present research was to determine adiponectin effect on human endometriotic stromal cells (escs) p...

Carbon nanotubes (CNT) possess excellent mechanical properties to play the role as reinforcement for imparting strength and toughness to brittle hydroxyapatite (HA) bioceramic coating. However, lack of processing technique to uniformly distribute multiwalled CNTs in HA coating and limited studies and sparse knowledge evincing toxicity of CNTs has kept researchers in dispute for long. In the cur...

Acting as hormone mimics or antagonists in the interaction with hormone receptors, endocrine disrupting chemicals (EDCs) have the potentials of disturbing the endocrine system in sex steroid hormone-controlled organs and tissues. These effects may lead to the disruption of major regulatory mechanisms, the onset of developmental disorders, and carcinogenesis. Especially, among diverse EDCs, xeno...

BACKGROUND It is well established that the growth of the prostate gland is a hormone-dependent phenomenon involving both androgenic and estrogenic control. Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate. METHODS The prostates...

The role of androgens in prostate cancer is obvious due to the fact that androgen signalling is the main regulator of prostate growth and function. Androgen deprivation therapy is a mainstay treatment for advanced prostate cancer. However, prostate cancer often becomes androgen-independent, which in consequence leads to lethal and incurable disease. In addition, oestrogens play a crucial role i...

Oestrogens protect neurons against excitatory amino acid-induced toxicity; however data on their interaction with particular subtype of glutamate receptors are sparse. Therefore in the present study we investigated oestrogen effects on kainate neurotoxicity in primary cortical neurons. The data showed that both oestradiol-17 beta and oestrone (100 nM and 200 nM) reduced kainate toxicity by ca. ...

Polychlorinated biphenyls (PCBs) and phytoestrogens were found to affect contractions of bovine uterus. Prostaglandins (PG) F2α and E2 are also involved in the uterine contractility. Hence the aim of these studies was to investigate the effect of PCBs and some phytoestrogens on PG secretion from endometrial cells obtained on days 1–5 of the oestrous cycle. Cells were incubated in aerated atmosp...