1. Serum sialic acid is a reputed cardiovascular risk factor, but the reason why this is so is not clear. We therefore studied its relationship with other known cardiovascular risk factors (particularly those associated with insulin resistance) in 100 healthy young subjects (54 females and 46 males, age 20.7+/-0.89 years). 2. There was a significant univariate correlation between serum total si...

OBJECTIVES This longitudinal study investigated whether or not plasma retinol-binding protein (RBP), recently referred to as RBP4, was a marker of insulin resistance in overweight subjects. METHODS We measured anthropometric markers as well as RBP, fasting glucose and insulin in 206 overweight subjects and repeated these measurements 36 months later. Subjects were grouped according to fasting...

Objective: This study aims to estimate and compare the time-course change in blood glucose levels by blood cells in serum, and plasma with or without preservatives, which may reflect the rate of glucose utilization by blood cells. Method: This laboratory-based cross-sectional study was carried out using a blood specimen of 28 participants among which 14 were diagnosed with diabetes and 14 were...

OBJECTIVE To investigate the clinical efficacy of gastric bypass surgery in non-obese patients with type 2 diabetes. METHODS Clinical data of 58 non-obese patients with type 2 diabetes (body mass index range from 22.1-25.8 kg/m(2)) were collected one year after gastric bypass surgery. Collected parameters included fasting plasma glucose, 2-hour postprandial blood glucose, glycosylated hemoglo...

BACKGROUND Several studies have shown associations between hyperglycemia and risk of cardiovascular disease (CVD) and mortality, yet glucose-lowering treatment does little to mitigate this risk. We examined whether associations between hyperglycemia and CVD risk were explained by underlying insulin resistance. METHODS In 60 middle-aged individuals without diabetes we studied the associations ...

abstract        background and objective: the association of triglyceride/high density lipoprotein-cholesterol (tg/hdl-c) ratio with fasting serum insulin, which is an alternative method of insulin resistance (ir) measurement, is well-recognized. thus, the measurement of tg/hdl-c ratio is useful to determine both ir and dyslipidemia, which itself is a characteristic of individuals with ir. ther...

The effects of a high-fat diet on ketonemia and other plasma parameters of gluconeogenesis and ketogenesis were studied in rabbits during feeding, during a 4-day fast, and again during refeeding. Arterial plasma glucose, lactate, total aminoacids, ketone bodies, insulin and glucagon were measured daily. In the fed state, the high-fat diet induced an increase in plasma NEFA and ketone bodies and...

Prenatal and early postnatal life experiences, reflected by size at birth and postnatal catch-up growth, contribute to the risk of developing the metabolic syndrome in adulthood, but their relative importance is unclear. Therefore, we determined the effects of restricted placental and fetal growth on components of the metabolic syndrome in young adult sheep and the relationships of the latter t...

CONTEXT Control of plasma glucose could prevent the progression of most of the complications of diabetes and hemoglobinA1c (HbA1c) is the most important criterion controlling these long-term complications. AIMS This study was performed to assess the effect of fasting plasma glucose (FPG) and two- hour postprandial plasma glucose (2hpp) levels on HbA1c. MATERIALS AND METHODS In this descript...

OBJECTIVES To investigate gender-specific relationships between cardiorespiratory fitness and factors that predict the development of diabetes and to identify the risk factors that predict fasting plasma glucose and 2-hour plasma glucose levels. INTRODUCTION Different risk factors (e.g., low cardiorespiratory fitness) may cause elevated plasma glucose levels in men compared to women. Therefor...