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Methods In the MONET trial, 256 patients with HIV RNA <50 copies/mL on current HAART, and no history of virological failure, switched to DRV/r 800/100 mg once daily, either as monotherapy (n=127) or with 2NRTI (n=129). HIV RNA was evaluated by the Roche Amplicor Ultrasensitive assay (lower detection limit=50 copies/mL), for all patient visits to Week 96. With this assay, “Optical Density=backgr...

Globally there is an increase in the number of people living with HIV at an advanced age (50 years and above). This is mainly due to prolonged survival following the use of highly active antiretroviral therapy. Living with HIV at an advanced age has been shown to be associated with a number of challenges, both clinical and immunological. This minireview aims at discussing the challenges encount...

INTRODUCTION HIV positive individuals are prone to malnutrition due to inadequate dietary intake. Additionally, in low-income countries, including Nigeria, stigmatization and discrimination result in a lack of support for HIV-positive individuals ultimately contributing to even further reduced food availability and inadequate dietary intake. This study aimed to determine the nutrirional status ...

Major Compulsory Revisions 1. The largest potential for bias would seem to come from the fact that some of the HAART users were previous users and were preferentially give HAART at the start of the program to avoid treatment interruptions. These people had a longer period of time from which to potentially benefit from HAART. It would seem that secondary analyses excluding these participants wou...

Objectives The life expectancy of HIV positive individuals has improved dramatically with the advent of HAART. The cohort of older people living with HIV is steadily increasing in size. Both advancing age and HIV are associated with an increased likelihood of comorbidities and polypharmacy independently, but little is known about their combined impact and how this will shape the care required f...

A 31 year old HIV infected woman developed neuropsychiatric problems soon after starting highly active antiretroviral therapy (HAART). Despite modifying and subsequently stopping HAART her condition progressively worsened. Cranial magnetic resonance imaging revealed multiple areas of abnormal signal suggestive of either a vasculitis or demyelination.

We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.

The purpose of the present study was to assess the relationship between the awareness of HAART, beliefs regarding transmission of HIV of persons taking HAART, norms associated with sexual risk behaviour, fear of HIV/AIDS, optimism of finding a cure or vaccine, and sexual behaviour in the general population of Sweden. A mail survey was sent to 4,000 randomly selected individuals aged 16-44 years...