نتایج جستجو برای: highly populated families
تعداد نتایج: 614322 فیلتر نتایج به سال:
The focus of structural biology is on studies of the highly populated, ground states of biological molecules; states that are only sparsely and transiently populated are more difficult to probe because they are invisible to most structural methods. Yet, such states can play critical roles in biochemical processes such as ligand binding, enzyme catalysis, and protein folding. A description of th...
Contemporary games are making significant strides towards offering complex, immersive experiences for players. We can now explore sprawling 3D virtual environments populated by beautifully rendered characters and objects with autonomous behavior, engage in highly visceral action-oriented experiences offering a variety of missions with multiple solutions, and interact in ever-expanding online wo...
Solution- and solid-state nuclear magnetic resonance (NMR) spectroscopy are highly complementary techniques for studying supra-molecular structure. Here they are employed for investigating the molecular chaperone αB-crystallin, a polydisperse ensemble of between 10 and 40 identical subunits with an average molecular mass of approximately 600 kDa. An IxI motif in the C-terminal region of each of...
Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In particular, the important role that structural genomics can play in identifying potential function is ...
We use the Rosetta de novo structure prediction method to produce three-dimensional structure models for all Pfam-A sequence families with average length under 150 residues and no link to any protein of known structure. To estimate the reliability of the predictions, the method was calibrated on 131 proteins of known structure. For approximately 60% of the proteins one of the top five models wa...
BACKGROUND Multilevel and multimodal interventions have been suggested for suicide prevention. However, few studies have reported the outcomes of such interventions for suicidal behaviours. METHODS We examined the effectiveness of a community-based multimodal intervention for suicide prevention in rural areas with high suicide rates, compared with a parallel prevention-as-usual control group,...
Background Woody plant diversity from the Amazonian savannas has been poorly quantified. In order to improve the knowledge on wood plants of these regional ecosystems, a tree inventory was carried out in four different habitats used by indigenous people living in the savanna areas of the Northern Brazilian Amazon. The habitats were divided into two types (or groups) of vegetation formations: fo...
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