This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order release kinetic while most of the previous formulations have shown Higuchi release kinetic. Considering the results from previous studies, ethyl cellulose, Carbopol 934P, Carbopol 974P, and Pemulen TR-1 were used at different amounts for preparation of the tablets by direct compression. The release ...

In this study an attempt was made to design and evaluate oral sustained release matrix tablets of ranolazine using Methocel K4M CR as the retardant polymer. Tablets were prepared by conventional wet granulation technique. Tablets were evaluated for parameters such as weight variation, hardness, friability and drug content. All the formulations showed compliance with pharmacopieal standards. In ...

Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. ...

tionen des lignins bei der Sulfatkochung. II. Modellversuche zur Spaltung von Arylalkyllatherbindingungen durch Alkali. Acta Chem. Scand. 16: 1713-29. 8. HANSON, K. R. AND .M. ZUCKER. 1963. The biosynthesis of chlorogenic acid and related conjugates of the hydroxycinnamic acids. J. Biol. Chem. 238: 1105-15. 9. HIGUCHr, T. 1957. Biochemical studies of lignin formation. II. Pihysiol. Plantarum 10...

By using a synthetic deoxyoligonucleotide probe designed to recognize the structural gene for cytochrome cc3 from Desulfovibrio vulgaris Hildenborough, a 3.7-kb XhoI genomic DNA fragment containing the cc3 gene was isolated. The gene encodes a precursor polypeptide of 58.9 kDa, with an NH2-terminal signal sequence of 31 residues. The mature polypeptide (55.7 kDa) has 16 heme binding sites of th...

Bi-specific OMT (EC 2.1.1.68) catalyzes the meta-specific methylation of caffeic acid and 5-hydroxyferulic acid to ferulic acid and sinapic acid, respectively (Higuchi, 1990). It is one of the key enzymes in angiosperm dicots mediating the formation of unique precursors for syringyl lignin, which is generally absent in gymnosperms (Higuchi, 1990). OMT has been purified and its cDNA clones isola...

Background: Polyesters have been attractive for development of drug delivery applications because of their biocompatible, biodegradable and non-toxic properties. The objective of work is a comparative study on the release characteristics of two drugs loaded poly (L-lactide) (PLLA) film. Progesterone (Pro) and lidocaine hydrochloride (LidH) were chosen as the hydrophobic and hydrophilic model dr...

Niosomes, as a kind of drug delivery system, is widely used for the topical lipophilic drugs. Optimization niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare optimized niosomal formulation simvastatin (nSIM), member statins, through experiment (Response Surface methodology). Optimized were characterized size, polydispersity index (PDI), entr...

This paper describes an evolvable hardware (EHW) system for generalized neural network learning. We have developed an ASIC VLSI chip, which is a building block to configure a scalable neural network hardware system. In our system, both the topology and the hidden layer node functions of a neural network mapped on the chips are dynamically changed using a genetic algorithm. Thus, the most desira...