Y. Bito, K. Hirata, T. Ebisu, Y. Kawai, Y. Otake, S. Hirata, T. Shirai, Y. Soutome, H. Ochi, M. Umeda, T. Higuchi, and C. Tanaka Central Research Laboratory, Hitachi, Ltd., Kokubunji-shi, Tokyo, Japan, Neurosurgery, Nantan General Hospital, Nantan-shi, Kyoto, Japan, Medical Informatics, Meiji University of Integrative Medicine, Nantan-shi, Kyoto, Japan, Neurosurgery, Meiji University of Integra...

Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, and Mitsuru Higuchi Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, Japan; Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan; and Institute o...

1. Philipsen HP, Reichart PA. Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol 1998;34:317-25. 2. de Andrade Sobrinho J, de Carvalho MB, Rapoport A, Saba LM. Odontogenic adenomatoid tumor of the mandible (adenoameloblastoma). Int Surg 1978;63:39-42. 3. Ide F, Mishima K, Saito I, Kusama K. Diagnostically challenging epithelial odontogenic tumors: a selective review ...

A dissolution test for fesoterodine low dose extended-release tablets using liquid chromatographic (LC) method equipped with a C18 monolithic column was developed and validated. LC system was operated isocratically at controlled temperature (40 °C) using a mobile phase of acetonitrile:methanol:0.03 M ammonium acetate (pH 3.8) (30:15:55, v/v/v), run at a flow rate of 1.5 mL/min and detected at 2...

Zidovudine-ethylcellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical free flowing microspheres having an entrapment efficiency of 32-54% were obtained. The effect of polymer-drug ratio, surfactant concentration for secondary emulsification process, volume of processing medium and stirring speed of secondary emulsification process was ev...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

This paper describes formulation considerations and in vitro evaluation of an oleic acid-based polyelectrolytic polymer-containing microemulsion drug delivery system designed for intranasal administration of a hydrophobic model drug Olanzapine. Drug-loaded microemulsions were successfully prepared by a water titration method. The microemulsion containing 4% oleic acid, 30% surfactant mixture of...

Fenofibrate lipospheres were prepared by the melt dispersion technique. Critical parameters influencing particle size and entrapment efficiency were optimized by applying the L9 Taguchi experimental design. Entrapment efficiency of up to 87 % was obtained for the optimized formulation on increasing olive oil up to 30 % in the lipid carrier. Particle size analysis by microscopy and SEM revealed ...

Statistical comparison of dissolution profiles under a variety of conditions relating to formulation characteristics, lot-to-lot, and brand-to-brand variation attracts interest of pharmaceutical scientist. The objective of this work is to apply several profile comparison approaches to the dissolution data of five-marketed aceclofenac tablet formulations. Model-independent approaches including A...