This experiment was designed to study the effects of caffeine on histomorphology testes prepubertal male Wistar rats. Prepubertal rats (25-28 days old), weighing between 50-60 g were randomly divided into three treatment groups (B, C and D) control (A) ten each. Group A received distilled water while Groups B, C, D respectively given daily dose 50 mg/kg, 100 200 mg/kg dissolved in for 14 by gav...

Introduction: Diabetes mellitus impairs the metabolism of carbohydrates, lipids and proteins, which leads to the dysfunction of the central and peripheral nervous system. This study evaluates the effects of an aloe vera hydro-alcoholic extract on diabetic neuropathy. Materials and Methods: For this study, 48 healthy male Sprague Dawley rats(weighed 250-200 g) were randomly divided in to t...

HIGHLIGHTS The gametogenesis of Biomphalaria glabrata was described. Oogenesis classified into five developmental stages. New histomorphometric parameters were described for oocytes. Spermatogenesis seven stages development. B. as a tool environmental and public health researches.

Parathyroid hormone (PTH) is a key regulator of bone turnover but can be oxidized in vivo, which impairs biological activity. Variable PTH oxidation may account for the rather poor correlation with indices chronic kidney disease. Here, we tested whether non-oxidized superior to total as marker 31 patients failure included from an ongoing prospective observational biopsy study and selected cover...

Metabolic bone disease is a major issue in chronic liver disease. Increased production of nitric oxide (NO) and elevation of endogenous opioids have been suggested to occur during cholestasis/cirrhosis. We aimed to investigate the involvement of nitrergic and opioidergic systems in bone loss after bile-duct-ligation (BDL) in rats using optical density (OD) evaluation and histomorphometric analy...

6-Mercaptopurine (6-MP) is an antimetabolite. The drug inhibits DNA synthesis of cells by acting as a false analog of purines. 6-MP displays a cytostatic and immunosuppressive activity. The studies carried out so far focus mostly on recognizing the clinical effectiveness of 6-MP, particularly in treating autoimmune diseases, whereas its effect on the osseous tissue still remains unknown. We exa...