نتایج جستجو برای: hno sensing
تعداد نتایج: 125714 فیلتر نتایج به سال:
Heart failure remains a leading cause of morbidity and mortality worldwide. Although depressed pump function is common, development of effective therapies to stimulate contraction has proven difficult. This is thought to be attributable to their frequent reliance on cAMP stimulation to increase activator Ca . A potential alternative is nitroxyl (HNO), the 1-electron reduction product of nitric ...
Nitric acid plays an important role in the heterogeneous chemistry of the atmosphere. Reactions involving HNO(3) at aqueous interfaces in the stratosphere and troposphere depend on the state of nitric acid at these surfaces. The vapor/liquid interface of HNO(3)-H2O binary solutions and HNO(3)-H(2)SO(4)-H2O ternary solutions are examined here using vibrational sum frequency spectroscopy (VSFS). ...
BACKGROUND Nitroxyl (HNO), a redox congener of nitric oxide (NO·), is a novel regulator of cardiovascular function, combining concomitant positive inotropic, lusitropic, and vasodilator properties. Moreover, HNO exhibits myocardial antihypertrophic and superoxide-suppressing actions. Despite these favorable actions, the impact of chronic HNO administration has yet to be reported in the context ...
A study has been conducted for the determination of arsenic in seagrass using inductively coupled plasma mass Ž . spectrometry ICP-MS with emphasis on sample digestion procedures and interference reduction. Open-vessel digestion with four different media, HClO rH SO rHNO H SO rHNO , HNO rH O , and HNO , was tested 4 2 4 3, 2 4 3 3 2 2 3 and compared. The HNO rH O mixture was found to be the mos...
Nitroxyl anion (HNONO(-)), the one-electron reduced form of nitric oxide (NO), induces positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we tested whether HNO/NO(-) augments systolic and diastolic function of failing hearts, and whether contrary to NO/nitrates such modulation enhances rather than blunts beta-adrenergic stimulation and is accompanied by...
Nitroxyl (HNO) may be formed endogenously by uncoupled nitric-oxide (NO) synthases, enzymatic reduction of NO or as product of vascular nitroglycerin bioactivation. The established HNO donor Angeli's salt (trioxodinitrate, AS) causes cGMP-dependent vasodilation through activation of soluble guanylate cyclase (sGC). We investigated the mechanisms underlying this effect using purified sGC and cul...
Nitroxyl (HNO) donors have potential benefit in the treatment of heart failure and other cardiovascular diseases. 1-Nitrosocyclohexyl acetate (NCA), a new HNO donor, in contrast to the classic HNO donors Angeli's salt and isopropylamine NONOate, predominantly releases HNO and has a longer half-life. This study investigated the vasodilatative properties of NCA in isolated aortic rings and human ...
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