The significance of any association between cardiovascular disease and circulating homocysteine concentrations is attracting considerable attention. The normal activities of the transsulfuration and remethylation pathways maintain intracellular homocysteine levels within a narrow range, and the controlled release of homocysteine into blood results in blood measurements that provide an accurate ...

Numerous case-control and prospective studies have identified elevated plasma homocysteine as a strong independent risk factor for cerebovascular, cardiovascular and peripheral vascular disease. Homocysteine is formed as a result of the breakdown of the dietary amino acid methionine. Once formed, homocysteine is either remethylated to methionine, or undergoes a trans-sulfuration reaction to for...

On the basis of recent retrospective and prospective studies, it is now widely accepted that increased total plasma homocysteine is a risk factor for cardiovascular disease. Impaired enzyme function as a result of genetic mutation or deficiency of the essential B vitamins folic acid, B12, and B6 can lead to hyperhomocysteinemia. Oxidized forms of homocysteine account for 98-99% of total plasma ...

Homocysteine is an independent risk factor for coronary, cerebral, and peripheral vascular diseases. Recent studies have shown that levels of homocysteine are elevated in patients with impaired hepatic function, but the precise role of homocysteine in the development of hepatic dysfunction is unclear. In this study, we examined the effect of homocysteine on hepatocyte proliferation in vitro. Ou...

Total homocysteine is defined as the sum of all homocysteine species in plasma/serum, including free and protein-bound forms. In the present review, we compare and evaluate several techniques for the determination of total homocysteine. Because these assays include the conversion of all forms into a single species by reduction, the redistribution between free and protein-bound homocysteine thro...

TO THE EDITOR: Jiang et al. (3) reported an important finding that vascular smooth cell migration was promoted by the resistin gene expression induced by ultrahigh concentrations of homocysteine (500 M). The homocysteine concentrations used by Jiang et al. were markedly higher than the physiological concentrations ( 100 M); therefore, the biological significance of the results of their study sh...

background: coronary artery disease (cad) is emerging as a major public health concern in most developing countries. during the past 10 years, the vast majority of over 100 case-control retrospective studies have shown that elevated plasma homocysteine level is a strong independent risk factor for coronary artery disease. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate and...

background: more recently, hyperhomocysteinemia was considered potentially as a reversible risk factor for venous thromboembolism. mild hyperhomocysteinemia occurs in approximately 5 to 7 percent of the general population. this study investigates the plasma homocysteine concentration of patients with and without deep venous thrombosis. methods: this descriptive case -control study was done on 5...

Objective: An association between high homocysteine levels and proteinuria in diabetic nephropathy has been shown. On the other hand, supplementation with folic acid lowers homocysteine concentration. We have studied the effects of folic acid supplementation on proteinuria in type 2 diabetic patients with overt proteinuria. Materials and Methods: Forty five (29 men and 16 women) type 2 diabe...