Flibanserin is a novel antagonist small molecule to treat the hypoactive sexual desire disorder (HSDD) in the premenopausal women. The present article is related to the structural and electronic properties study and docking analysis of the title compound with 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor. To access these aims, the molecular structure of the said compound was optimized usin...

Flibanserin, a drug with mixed effects on serotonergic and dopaminergic neurotransmitter systems, has recently been recommended for FDA approval, albeit withmany restrictions, for the treatment of low sexual desire in premenopausal women. The sexual side effects of antidepressants with at least partially known mechanisms of action indicate that flibanserin should enhance sexual response. Rather...

Abstract Introduction According to the Global Consensus Position Statement on Use of Testosterone Therapy for Women, testosterone can significantly improve desire in menopausal women with hypoactive sexual disorder. Based safety and efficacy different formulations, recommended treatment is 1/10th a man’s dose, using government approved topical gel or solution, AndroFeme which use Australia. The...

Few studies address alteration of sexual function in women with diabetes and chronic kidney disease (CKD). Quality of life surveys suggest that discussion of sexual function and other reproductive issues are of psychosocial assessment and that education on sexual function in the setting of chronic diseases such as diabetes and CKD is widely needed. Pharmacologic therapy with estrogen/progestero...

INTRODUCTION There are problems with the existing definition of hypoactive sexual desire disorder (HSDD) in that desire for sex and sexual fantasy are not a universal experience. AIMS To explore: (i) women's motivations to engage in sexual activity; (ii) frequency and predictors of sexual fantasies; (iii) sexual arousal; (iv) recognition of sexual arousal; and (v) association between relation...

Abstract Introduction Research on the relationship between physical activity (PA) and female sexual dysfunction (FSD) is lacking. Objectives To investigate clinical, psychological, correlates of PA in women with FSD. Methods A non-selected series n=322 pre- post-menopausal patients consulting for FSD was retrospectively studied. Regular involvement its frequency (<1 hour/week: sedentary,...