losartan potassium, valsartan , telmisartan and irbesartan are angiotensin-ii-receptor antagonists (ara ii) group which used in treatment of hypertension alone or in combination with other drugs mainly hydrochlorothiazide. rp- hplc method was developed for the assay of three angiotensin-ii-receptor antagonists (ara-iis) in presence of hydrochlorothiazide. the method was performed by reversed ph...

BACKGROUND Ensuring the appropriate use of migraine therapies is an important consideration for care providers, patients, employers, and managed care organizations (MCOs) because of the high cost of treatment for this fairly prevalent disabling disease. A review of utilization of serotonin 5-HT1 receptor agonists (triptans) in an MCO determined that about 24% of the patients who received tripta...

The gastropyloric receptor (GPR) cells are a set of cholinergic/serotonergic mechanosensory neurons that modulate the activity of neural networks in the crab stomatogastric ganglion (STG). Stimulation of these cells evokes a variety of slow modulatory responses in different STG neurons that are mimicked by exogenously applied serotonin (5-HT); these responses include tonic inhibition, tonic exc...

1. The effects of 5-hydroxytryptamine (5-HT) were studied in vitro on bladder and urethral muscle strips from the rabbit. 5-HT produced dose-dependent contraction in the detrusor and urethra. 2. The 5-HT-induced contraction could be dose-dependently inhibited by the 5-HT3 antagonists MDL 72222, ICS 205-930 and BRL 43694. No effect of ketanserin, methysergide or metitepine was observed on the co...

The neuropeptide S receptor (NPS receptor) responds to the 20 amino-acid peptide derived from a precursor (NPS, P0C0P6). NPS activates its at low nanomolar concentrations elevating intracellular cAMP and calcium levels [71]. Currently, some peptidic small molecule antagonists are available as research tools [27, 79, 8, 59]. No ligands currently used clinically.

Serotonin is probably unique among the monoamines in that its effects are subserved by as many as 13 distinct heptahelical, G protein-coupled receptors (GPCRs) and a ligand-gated ion channel family (5-HT3). These receptors are divided into seven distinct classes (5-HT1 to 5-HT7) largely on the basis of their structural, transductional and operational characteristics. While this degree of physic...