When released from damaged erythrocytes free heme not only provides a source of iron for invading bacteria but also highly toxic due to its ability to catalyze free radical formation. Hemopexin (Hx) binds free heme with very high-affinity and thus protects against heme toxicity, sequesters heme from pathogens, and helps conserve valuable iron. Hx is also an acute-phase serum protein (APP), whos...

Seeds from the myxospermous species Plantago ovata release a polysaccharide-rich mucilage upon contact with water. This seed coat derived mucilage is composed predominantly of heteroxylan (HX) and is utilized as a gluten-free dietary fiber supplement to promote human colorectal health. In this study, a gamma-irradiated P. ovata population was generated and screened using histological stains and...

For better design and optimization of the heat exchanger (HX), forced convective transfer flow characteristics supercritical carbon dioxide (SCO2) in a water-cooled experimental counter-flow tube-in-tube HX were studied numerically with three-dimensional Reynolds-averaged Navier-Stokes equations shear stress transport (SST) turbulence model by using computational fluid dynamics method ANSYS CFX...

Hydrogen exchange (HX) monitored by mass spectrometry (MS) is a powerful analytical method for investigation of protein conformation and dynamics. HX‐MS monitors isotopic exchange of hydrogens in protein backbone amides and thus serves as a sensitive method for probing protein conformation and dynamics along the entire protein backbone (except for proline) (Figure 1.1). Historically, the monito...

ÐThe e€ect of defoliation on growth and on levels and allocation patterns of hydroxamic acids (Hx) in maize seedlings was evaluated 6 days after treatment. No signi®cant di€erences were found between defoliated and nondefoliated plants for the Hx concentration, relative Hx content and Hx-aglucone to Hxglucoside ratio in shoots, roots and root exudates, with the exception of Hx concentration in ...

Regenerative processes in brain pathologies require the production of distinct neural cell populations from endogenous progenitor cells. We have previously demonstrated that oligodendrocyte progenitor cell (OPC) proliferation is crucial for oligodendrocyte (OL) regeneration in a mouse model of neonatal hypoxia (HX) that reproduces diffuse white matter injury (DWMI) of premature infants. Here we...

BACKGROUND Endothelial dysfunction is considered as the initiating process and pathological basis of cardiovascular disease. Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS), inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) are key enzymes with opposing actions in inflammation and oxidative stress, which are believed to be the major driver of endothelial dysfunction. A...

OBJECTIVE We previously reported that hemopexin (Hx), a heme scavenger, is significantly increased and associated with proinflammatory high-density lipoprotein under atherogenic conditions. Although it is established that Hx together with macrophages plays a role in mitigating oxidative damage, the role of Hx in the development of atherosclerosis is unknown. APPROACH AND RESULTS We used Hx an...

Administration of hexamethonium (Hx) and atropine inhibits myoelectric and motor activity and then evokes a stimulatory effect called rebound excitation (RE) in the ovine small bowel. RE has not been precisely characterized so far and it is possible that it is composed of different types of motility. This study was thus devoted to characterizing these excitatory changes in the myoelectric and m...

Introduction. The main part of skeletal muscle adenosine5'-triphosphate (ATP) is restored by inosine monophosphate (IMP) reamination in the purine nucleotide cycle. The intramuscular resources of IMP may be resynthesized via the quick and economical salvage pathway, in which muscle hypoxanthine (Hx) is reconverted to IMP by hypoxanthineguanine phosphoribosyl transferase (HGPRT). IMP is subseque...