CONTEXT AND OBJECTIVES The buccal mucosa presents a unique surface for non-invasive drug delivery and also avoids first-pass metabolism. The objective of this study was the formulation development of polymeric mucoadhesive lyophilized wafers as a matrix for potential buccal drug delivery. MATERIALS AND METHODS Differential scanning calorimetry (DSC) was used to develop an optimum freeze-cycle...

Experiments are reported in which it is shown that if rabbits are deprived of food, the lesions resulting from injection of vaccinia are either fewer or smaller; presumably this is partially explainable on reduction of available nutrients in the cell. The number and character of the lesions are also modified by the state of hydration of the interstitial tissues: If the amount of interstitial fl...

Corneal hydration and transparency still present multiple dilemmas to the inquiring investigator. Transparency is best explained by the oriented-lattice theory of Maurice, but, except for partly adequate electron micrographs, there is no objective evidence for the presence of such a lattice. Further, other transparent ocular structures are not constructed in this way. Relative dehydration and h...

This paper deals with the study of calcium sulfoaluminate (CSA) and geopolymeric (GEO) binders as alternatives to ordinary Portland cement (OPC) for the production of more environmentally-friendly construction materials. For this reason, three types of mortar with the same mechanical strength class (R3 ≥ 25 MPa, according to EN 1504-3) were tested and compared; they were based on CSA cement, an...

OBJECTIVE This study aimed to investigate the effects of BCRP expression on tumor recurrence, metastasis and treatment tolerability. METHODS A VX2 rabbit liver tumor model was established. Division was randomly into 4 groups: namely saline control group; A group, given hydration lipiodol; B group, Ad-p53; and C group, Ad-p53+hydration lipiodol. After the intervention, samples were collected t...

In this article the sound velocity through a mix is correlated to the hydration degree of the mix. Models are presented predicting the sound velocity through fresh slurries and hardened products. These two states correspond to the starting and finishing point of the hydration process. The present research shows that a linear relation between the amount of hydration-product (gypsum) formed (Smit...

Although healthy dentin is invariably hydrated in vivo, from a perspective of examining the mechanisms of fracture in dentin, it is interesting to consider the role of water hydration. Furthermore, it is feasible that exposure to certain polar solvents, e.g., those found in clinical adhesives, can induce dehydration. In the present study, in vitro deformation and fracture experiments, the latte...

INTRODUCTION AND OBJECTIVES The study was conducted to evaluate soft tissue hydration and mass through pattern analysis of vector plots as height, normalized resistance, and reactance measurements by bioelectric impedance vector analysis (BIVA) in patients with breast cancer. MATERIALS AND METHODS Whole-body measurements were made with ImpediMed bioimpedance analysis SFB7 BioImp v1.55 (Pinken...

Hydration water is essential for a protein to perform its biological function properly. In this study, the dynamics of hydration water around F-actin and myosin subfragment-1 (S1), which are the partner proteins playing a major role in various cellular functions related to cell motility including muscle contraction, was characterized by incoherent quasielastic neutron scattering (QENS). The QEN...

Rapid Alkalinization Factors (RALFs) are plant peptides that rapidly increase the pH of plant suspension cell culture medium and inhibit root growth. A pollen-specific tomato (Solanum lycopersicum) RALF (SlPRALF) has been identified. The SlPRALF gene encodes a preproprotein that appears to be processed and released from the pollen tube as an active peptide. A synthetic SlPRALF peptide based on ...