In this study, it is aimed to produce composite hydroxyapatite (HA) gelatin microspheres (HA-Gel) intended for drug delivery applications. The polymer network within the HA particle-matrix can be facilitated as a carrier system. dissolution of in physiological medium allows release controlled manner and also develop cell-microsphere interactions. Gelatin functionalized bare granules were produc...

Local drug delivery systems are an effective approach in the treatment of purulent–septic inflammation bone tissue. Chemically bonded multiphase ceramics based on calcium-deficient carbonate-substituted hydroxyapatite combine resorbability, osteoconductivity, and possibility volumetric incorporation antibiotics. Macroporosity is regulated by concentration polyethylene glycol granules introduced...

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as di...

OBJECTIVES Biphasic calcium phosphate (BCP) is frequently used as bone substitute and often needs to be combined with autologous bone to gain an osteoinductive property for guided bone regeneration in implant dentistry. Given the limitations of using autologous bone, bone morphogenetic protein-2 (BMP2)-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particles (BMP2-cop.Bio...

OBJECTIVES To explore the therapeutic potential of combining bone marrow-derived mesenchymal stem cells (BM-MSCs) and hydroxyapatite (HA) granules to treat nonunion of the long bone. METHODS Ten patients with an atrophic nonunion of a long bone fracture were selectively divided into two groups. Five subjects in the treatment group were treated with the combination of 15 million autologous BM-...