The impact of JAK/STAT inhibitors, which are used in various inflammatory diseases, on cardiovascular risk is controversial and has recently raised safety concerns. Our study investigates the direct effects tofacitinib macrophage cholesterol metabolism, crucial for atherosclerosis plaque development stability. Cultured human macrophages THP-1 were to assess cell efflux synthesis via radioisotop...

Objectives: Lallemantia royleana (Benth. in Wall.) Benth. (Lamiaceae) is a medicinal plant used in Iranian traditional and folklore medicine in the treatment of various nervous, hepatic, and renal diseases. In the present study, whole seeds of the herb were prepared and evaluated for hypolipidemic activities using an animal model. Materials and Methods: Animals were fed normal diets or diets su...

objective(s): we examined the effects of endurance exercise in the presence of bunium persicum extract administration on lipid profile and cardiorespiratory capacity in hypercholesterolemic male mice. materials and methods: forty male hypercholesterolemic mice were divided into four groups: vehicle, endurance exercise (ee), bunium persicum extract (bpe), and ee + bpe. the exercise protocol was ...

background: diabetes mellitus type 2 with dyslipidemia is a common disease. previous studies suggest that chemical constituent present in pinus eldarica (p. eldarica) nut posesess antioxidant properties and positively affect glucose metabolism. however blood glucose and cholesterol lowering effects of p. eldarica nut have not been studied so far. objective: the present study was undertaken to e...

Hypercholesterolemia is one of the potential risks cardiovascular heart disease (CHD). An early diagnosis and treatment attenuate risk CHD. Besides statin prescription for hypercholesterolemia, functional food has an added value to ameliorate risk. This study was conducted analyse significant effect grey oyster mushroom (Pleurotus pulmonarius) on hypercholesterolemia. Thirty-six Wistar-Kyoto ra...

We studied the effects of hypercholesterolemia on the vascular responses of proximal and distal parts of the rabbit coronary circulation in two consecutive studies. For 12 weeks, New Zealand White rabbits were fed a control diet or a diet with 1% cholesterol dissolved in either 3% coconut oil (study A) or ether (study B). Isolated proximal epicardial and distal intramyocardial coronary arteries...

Our aim was to test, through a crossover, double-blind, placebo-controlled randomized clinical trial, if a short-term treatment with 10 mg monacolins combined with antioxidants could improve lipid pattern, high-sensitivity C-reactive protein (hs-CRP), and endothelial function in a small cohort of moderately hypercholesterolemic subjects. Thus, 25 healthy, moderately hypercholesterolemic subject...

The anti-hypercholesterolemic effect of berbamine (BBM) isolated from Rhizoma Coptidis (RC) was investigated in hypercholesterolemic zebrafish model induced by high-cholesterol (HC) diet. Zebrafish embryo assay revealed no significant difference in morphology and cell death with the treatment of BBM less than 20 μg/mL. In zebrafish larvae, the fluorescently labeled cholesterol in caudal artery ...

OBJECTIVE Cardiovascular disease is the leading cause of mortality in women in the United States. Aggressive treatment of modifiable risk factors (e.g., hypercholesterolemia) is essential in reducing disease burden. Despite guidelines recommending the use of statin treatment in hypercholesterolemic women, this patient group is often undertreated. This subgroup analysis of the Statin Therapies f...

1. Sbarouni E, Kyriakides ZS, Kremastinos D. The effect of hormone replacement therapy alone and in combination with simvastatin on plasma lipid levels of hypercholesterolemic postmenopausal women with coronary artery disease. J Am Coll Cardiol 1998;32:1244 –50. 2. Fak AS, Erenus M, Tezcan H, Caymaz O, Atagündüz P, Tokay S, Toprak A, Oktay Ş, Oktay A. Effects of simvastatin alone and in combina...