Russell’s viper being one of the most venomous snake species in Asia causes significant amount bites and deaths due to neurotoxicity, coagulopathy, haemorrhage, cardiotoxicity, myotoxicity, hypotension, oedema, tissue damage convulsion. Treatment with monoclonal antibodies, anti-snake venom is only medically approved treatment available for envenomation has many limitations side effects such as...

In this work, the acridine nucleus was used as a lead-compound for structural modification by adding different substituted thiosemicarbazide moieties. Eight new (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide derivatives (3a-h) were synthesized, their antiproliferative activities were evaluated, and DNA binding properties were performed with calf thymus DNA (ctDNA) by electronic a...

Purpose: To develop a simple, rapid and improved colorimetric method for the assay of reserpine in tablets Method: The method is based on the aromatic ring coupling of reserpine with 4-carboxyl-2,6dinitrobenzene diazonium ion with the consequent formation of an azo adduct. Optimization of reaction conditions and validation were carried out and the method applied to assay of reserpine in tablets...

Ever since Ehrlich described the megaloblasts seen in pernicious anemia during relapse, there have been attempts by many investigators to produce experimentally an anemia similar in all respects to human pernicious anemia. Macrocytic anemia with the megaloblastic type of erythrocytic regeneration in the bone marrow, achlorhydria, and a specific response to a substance containing the anti-anemic...

INTRODUCTION We reported a case of hemophagocytic syndrome complicating microscopic polyangitis presented by crescentic glomerulonephritis. CASE PRESENTATION A 22-year-old female patient originated from Dakar, Senegal presented with nephrotic syndrome and rapidly progressive glomerulonephritis. On physical examination, we noticed hyperchromic diffuse punctilious purpura skin lesions predomina...

Thrombocytopenia-associated multiple organ failure (TAMOF) has a high mortality rate when not treated, and early detection of TAMOF is very important diagnostically and therapeutically. We describe herein our experience of early detection of TAMOF, using an automated hematology analyzer. From 498,390 inpatients, we selected 12 patients suspected of having peripheral schistocytosis, based on the...

The cytotoxic activity of amino (3a-e), aza-1-antraquinone (4a-e) lapachol derivatives against Ehrlich carcinoma and human K562 leukemia cells was investigated. Cell viability was determined using MTT assay, after 48 (Ehrlich) or 96 h (K562) of culture, and vincristine (for K562 leukemia) and quercetin (for Ehrlich carcinoma) were used as positive controls. The results showed dose-dependent gro...

Caulobacter phage phi 6, previously reported to adsorb specifically to bacterial flagella, was shown here to attach to pili more frequently than to flagella. Phage phi 6 was shown to contain double-stranded DNA by circular dichroism spectroscopy and thermal denaturation accompanied by a hyperchromic shift at 260 nm. Morphologically, phage phi 6 fits group B2 (H.-W. Ackermann, in A. I. Laskin an...

Excretion in Hepatic Cirrhosis, A.M.A. Arch. intern. Med., 108, 41. FRENCH, H. (1909): Sixty Cases of Pernicious Anaemia, Guy's Hosp. Rep., 63, 2. GRANVILLE, N., and DAMESHEK, W. (1958): Haemochromatosis with Megaloblastic Anaemia. Response to Folic Acid Therapy, New Engl. J. Med., 258, 586. HARVIER, P., and MALLARME, J. (1938): Biermer Disease of Hepatomegalic Form with Pigmentations Simulatin...

SEVERE ANEMIA in mice which had been kept on a diet of meat only has recently been described.”2 The anemia, which was mainly macrocytic and slightly hyperchromic,3 could not be cured or prevented by any of the hematopoietic factors such as iron, pyridoxine, folic acid or vitamin B12 alone or in combination.2 Replacement of one-quarter of the muscle meat by liver prevented the anemia completely....