Ehlers-Danlos syndrome is a heterogeneous connective tissue condition characterized by varying degrees of skin hyperextensibility, joint hypermobility, and vascular fragility. Joint dislocations, musculoskeletal pain, atrophic scars, easy bleeding, vessel/viscera rupture, severe scoliosis, and obstetric complications may occur. These manifestations are secondary to abnormal collagen, with speci...

Joint hypermobility syndrome (JHS) is a complex connective tissue disorder characterized by excessive joint mobility and chronic musculoskeletal pain. The condition extends beyond the joints can affect various systems such as skin, gastrointestinal tract, neurological system, cardiovascular necessitating multidisciplinary approach to optimize care. Notably, prevalence of JHS higher in young ind...

Ehlers-Danlos syndrome (EDS) is a heterogenous group of inherited disorders of connective tissue characterized by fragility of the skin and blood vessels, hyperextensibility of the skin and joint hypermobility. Cutis laxa is characteized clinically by lax, pendulous skin and histologically by loss of elastic tissue in the dermis. There are some reports of coexistence of cutis laxa with ot...

Hand dysfunction is commonly linked to ligamentous laxity (Murray 2006). The carpometacarpal joint (CMCJ) of the thumb may be particularly susceptible to weakened ligamentous constraints in the Ehlers-Danlos syndrome (Moore et al 1985). Symptoms may only present if the joint has been subject to excessive trauma, overuse or misuse and thus strains of the surrounding muscles and ligaments may hav...

The case of a patient with visceroptosis and Ehlers-Danlos syndrome hypermobility type (RDS-HT) is reported here. The literature on this unusual but probably under-recognized complication is reviewed.

A patient with marfanoid habitus wasadmitted to the General Hospital, Kuala Lumpur in October 1985 for surgical closure of an atrial septal defect. He was suspected to have Marfan Syndrome but there was no involvement of the aorta nor the eye. The clinical features were intermediate between that of the Marfan Syndrome and the Ehler's Danlos Syndrome. It is suggestedthat this could be a separate...