In our first 200 cases of primary hyperparathyroidism confirmed by operation 12 were also shown to have a long history either of a malabsorption syndrome or of chronic renal-glomerular failure. We consider that they first went through a phase of secondary hyperparathyroidism, during which one or more of the glands became autonomous adenamata. This then produced the biochemical changes of "prima...

BACKGROUND Primary hyperparathyroidism is an endocrinopathic condition characterized by hypersecretion of parathyroid hormone. Excess parathyroid hormone results in an altered state of osseous metabolism involving bone resorption and tissue change known as osteitis fibrosa cystica, which is the end stage of primary hyperparathyroidism. Osteitis fibrosa cystica is associated with the development...

INTRODUCTION Mutation testing for the MEN1 gene is a useful method to diagnose and predict individuals who either have or will develop multiple endocrine neoplasia type 1 (MEN 1). Clinical selection criteria to identify patients who should be tested are needed, as mutation analysis is costly and time consuming. This study is a report of an Australian national mutation testing service for the ME...

OBJECTIVE To summarize the management of hyperparathyroidism at a tertiary care hospital in Lahore, so that the disease characteristics specific to our population could be identified. Also to determine if focused parathyroidectomy was successful without intra operative localization studies. METHODS Retrospective analysis was conducted on all cases of hyperparathyroidism, managed at the East S...

Aetiology and pathogenesis A large number of diseases can lead to hypercalcaemia (table). In most instances the underlying cause is either primary hyperparathyroidism or malignant disease; the many other causes are rarely encountered even within specialist units. The prevalence of primary hyperparathyroidism and hypercalcaemia of malignancy varies with the population sampled. In ambulant subjec...

obesity is one of the health problems in the developing and developed countries. obesity subjects the individuals with metabolic and endocrine disorders. it is obvious that vitamin d deficiency or insufficiency may lead to secondary hyperparathyroidism. thus, obesity increases the risk of vitamin d deficiency. considering the high prevalence of vitamin d deficiency in children and adolescents w...

Our understanding of the evolving clinical profile of primary hyperparathyroidism has changed significantly.Recently substantial insights has been gained into its metabolic bone profile in particular. The epidemiology of primary hyperparathyroidism has fluctuated widely, in large part due to the availability of multi channel chemistry screening. Many patients nowadays are thus discovered throug...

background secondary hyperparathyroidism (shpt) is a prevalent disorder in patients with chronic kidney disease. it is proffered that there is a contradictory relation between serum level of vitamin c and parathyroid hormone (pth) in hemodialysis patients with secondary hyperparathyroidism. objectives the goal of this study was to assess the effects of the supplemental vitamin c on parathyroid ...

Maternal primary hyperparathyroidism causing hypercalcemia during pregnancy can suppress fetal and neonatal parathyroid hormone secretion. We report a newborn with transient hypoparathyroidism presented by hypocalcemic seizure and tetany on the 21st postnatal day in whom the final diagnosis was asymptomatic maternal primary hyperparathyroidism. Neonatal hypocalcemia usually occurs early in life...