Evaluation of Peripheral and Central Components of Action of Angiotensin on the Sympathetic Nervous System. B. G. ZIMMERMAN 1 Comparative Myocardial Depressant and Antiarrhythmic Properties of d-Propranolol, dl-Propranolol and Quinidine. WILLIAM W. PARMLEY AND EUGENE BRAUNWALD 11 Effects of Temperature and Ouabain on the Rate of Action of Calcium on Atrial Contractions. SANDRA SABATINI-SMITH AN...

Mathematical models of the action potential in the periphery and center of the rabbit sinoatrial (SA) node have been developed on the basis of published experimental data. Simulated action potentials are consistent with those recorded experimentally: the model-generated peripheral action potential has a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase ...

Evaluation of Peripheral and Central Components of Action of Angiotensin on the Sympathetic Nervous System. B. G. ZIMMERMAN 1 Comparative Myocardial Depressant and Antiarrhythmic Properties of d-Propranolol, dl-Propranolol and Quinidine. WILLIAM W. PARMLEY AND EUGENE BRAUNWALD 11 Effects of Temperature and Ouabain on the Rate of Action of Calcium on Atrial Contractions. SANDRA SABATINI-SMITH AN...

Evaluation of Peripheral and Central Components of Action of Angiotensin on the Sympathetic Nervous System. B. G. ZIMMERMAN 1 Comparative Myocardial Depressant and Antiarrhythmic Properties of d-Propranolol, dl-Propranolol and Quinidine. WILLIAM W. PARMLEY AND EUGENE BRAUNWALD 11 Effects of Temperature and Ouabain on the Rate of Action of Calcium on Atrial Contractions. SANDRA SABATINI-SMITH AN...

Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sino-atrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in X...

This paper describes the case of a young man with progressive muscular dystrophy who had supraventricular arrhythmias and intractable congestive failure. Hemodynamic studies and left cineventriculographic findings were compatible with a diagnosis of severe left ventricular failure. Coronary cinearteriography showed an abrupt ending of the artery to the sino-atrial node. At necropsy, a noninflam...

Atrial trabeculae (studied in voltage-clamping conditions and in the presence of 0.5 mmol/l BaCl2 to abolish gK1) responded to 1 s hyperpolarizations to beyond approximately E = -140 mV (from HP of about E = -80 mV) with an inwardly directed current increasing with time. Quite similar results were obtained with enzymatically dissociated frog atrial cells studied in whole cell voltage clamp with...

Sinus node dysfunction (SND) is commonly encountered in the clinic. The clinical phenotype ranges from asymptomatic sinus bradycardia to complete atrial standstill. In some cases, sinus bradycardia is associated with other myocardial conditions such as congenital abnormalities, myocarditis, dystrophies, cardiomyopathies as well as fibrosis or other structural remodeling of the SA node.1-8 Altho...

"Funny" (f) channels underlie the cardiac "pacemaker"I(f) current, originally described as an inward current activated on hyperpolarization to the diastolic range of voltages in sino-atrial node myocytes [Brown, HF, DiFrancesco, D, Noble, SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-236]. The involvement of funny channels in the generation and modulation of cardiac pacemake...